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中华产科急救电子杂志 ›› 2017, Vol. 06 ›› Issue (01) : 42 -46. doi: 10.3877/cma.j.issn.2095-3259.2017.01.011

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产科弥散性血管内凝血的基础与临床研究
潘秀玉1, 刘慧姝1,()   
  1. 1. 510623 广州市妇女儿童医疗中心产科
  • 收稿日期:2016-11-22 出版日期:2017-02-18
  • 通信作者: 刘慧姝

Basic and clinical progress of obstetric disseminated intravascular coagulation

Xiuyu Pan1, Huishu Liu1()   

  • Received:2016-11-22 Published:2017-02-18
  • Corresponding author: Huishu Liu
引用本文:

潘秀玉, 刘慧姝. 产科弥散性血管内凝血的基础与临床研究[J]. 中华产科急救电子杂志, 2017, 06(01): 42-46.

Xiuyu Pan, Huishu Liu. Basic and clinical progress of obstetric disseminated intravascular coagulation[J]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2017, 06(01): 42-46.

弥散性血管内凝血(disseminated intravascular coagulation, DIC)是各种产科及非产科因素导致的危及生命的状态。产科DIC存在引起DIC的潜在基础疾病,包括胎盘早剥、产后出血、子痫前期、子痫、HELLP综合征、妊娠期急性脂肪肝、感染性流产、羊水栓塞和胎儿宫内死亡等。本文就产科DIC的基础与临床研究进展进行阐述。

Disseminated intravascular coagulation(DIC) is a life-threatening state due to kinds of obstetric and non-obstetric disorders. DIC does not occur in isolation and is resulted from underlying basal disorders in pregnancy, including placental abruption, postpartum hemorrhage, preeclampsia, eclampsia, HELLP syndrome, acute fatty liver of pregnancy, septic abortion, amniotic fluid embolism, fetal demise, etc. This article focuses on the obstetric DIC of basic research and clinical aspects.

[1]
Levi M, Ten Cate H. Disseminated intravascular coagulation [J]. N Engl J Med, 1999, 341(8): 586-592.
[2]
Erez O, Novack L, Beerweisel R, et al. DIC Score in Pregnant Women-A Population Based Modification of the International Society on Thrombosis and Hemostasis Score [J]. PLoS One, 2014, 9(4): e93240.
[3]
Erez O, Mastrolia SA, Thachil J. Disseminated intravascular coagulation in pregnancy: insights in pathophysiology, diagnosis and management [J]. Am J Obstet Gynecol, 2016, 213(4): 452-463.
[4]
Lanir N, Aharon A, Brenner B. Procoagulant and anticoagulant mechanisms in human placenta [J]. Semin Thromb Hemost, 2003, 29(2):175-184.
[5]
Lockwood CJ, Krikun G, Schatz F. Decidual cell-expressed tissue factor maintains hemostasis in human endometrium [J]. Ann N Y Acad Sci, 2001, 943: 77-88.
[6]
Schatz F, Krikun G, Caze R, et al. Progestin-regulated expression of tissue factor in decidual cells: implications in endometrial hemostasis, menstruation and angiogenesis [J]. Steroids, 2003, 68(10-13): 849-860.
[7]
Hellgren M. Hemostasis during normal pregnancy and puerperium [J]. Semin Thromb Hemost, 2003, 29(2): 125-130.
[8]
高旖鑫,梁国强,蒋艳敏,等. 不同孕期妇女FⅩ和FⅫ活性变化 [J]. 微循环学杂志,2013, 23(2): 57-58.
[9]
Brenner B. Haemostatic changes in pregnancy [J]. Thromb Res, 2004, 114(5-6): 409-414.
[10]
James AH, Rhee E, Thames B, et al. Characterization of antithrombin levels in pregnancy [J]. Thromb Res, 2014, 134(3): 648-651.
[11]
Erez O, Romero R, Hoppensteadt D, el al. Tissue factor and its natural inhibitor in pre-eclampsia and SGA [J]. J Matern Fetal Neonatal Med, 2008, 21(12):855-869.
[12]
Thachil J, Toh CH. Disseminated intravascular coagulation in obstetric disorders and its acute haematological management [J]. Blood Rev, 2009, 23(4):167-176.
[13]
Rattray DD, O′Connell CM, Baskett TF. Acute disseminated intravascular coagulation in obstetrics: a tertiary centre population review (1980 to 2009) [J]. J Obstet Gynaecol Can, 2012, 34(4): 341-347.
[14]
Levi M, Van der Poll T. Inflammation and coagulation [J]. Crit Care Med, 2010, 38(2 Suppl): S26-S34.
[15]
Pacheco LD, Saade G, Hankins GD, et al. Amniotic fluid embolism: diagnosis and management [J]. Am J Obstet Gynecol, 2016, 215(2):B16-B24.
[16]
Cunningham FG, Nelson DB. Disseminated Intravascular Coagulation Syndromes in Obstetrics [J]. Obstet Gynecol, 2015, 126(5): 999-1011.
[17]
Hall DR. Abruptio placentae and disseminated intravascular coagulopathy [J]. Semin Perinatol, 2009, 33(3):189-195.
[18]
Dam PV. Disseminated intravascular coagulation and the syndrome of hemolysis, elevated liver enzymes, and low platelets in severe preeclampsia [J]. Obstet Gynecol, 1989, 73(1): 97-102.
[19]
Levi M, Meijers JC. DIC: which laboratory tests are most useful [J]. Blood Rev, 2011, 25(1): 33-37.
[20]
中华医学会血液学分会血栓与止血学组. 弥散性血管内凝血诊断与治疗中国专家共识(2012年版) [J].中华血液学杂志,2012, 33(11): 978-979.
[21]
Jr TF, Toh CH, Hoots WK, et al. Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation [J]. Thromb Haemost, 2001, 86(5): 1327-1330.
[22]
Gando S, Iba T, Eguchi Y, et al. A multicenter, prospective validation of disseminated intravascular coagulation diagnostic criteria for critically ill patients: comparing current criteria [J]. Crit Care Med, 2006, 34(3):625-631.
[23]
中华医学会血液学分会血栓与止血学组. 弥散性血管内凝血诊断与治疗中国专家共识(2017年版) [J].中华血液学杂志,2017, 38(5): 361-363.
[24]
Wang L, Matsunaga S, Mikami Y, et al. Pre-delivery fibrinogen predicts adverse maternal or neonatal outcomes in patients with placental abruption [J]. J Obstet Gynaecol Res, 2016, 42(7):796-802.
[25]
Charbit B, Mandelbrot L, Samain E, et al.The decrease of fibrinogen is an early predictor of the severity of postpartum hemorrhage [J]. J Thromb Haemost, 2007, 5(2):266-273.
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