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中华产科急救电子杂志 ›› 2019, Vol. 08 ›› Issue (02) : 82 -86. doi: 10.3877/cma.j.issn.2095-3259.2019.02.005

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妊娠合并系统性红斑狼疮的活动期管理
汪丽萍1, 钟梅1,()   
  1. 1. 510515 广州,南方医科大学附属南方医院妇产科
  • 收稿日期:2019-02-11 出版日期:2019-05-18
  • 通信作者: 钟梅

Management of severe systemic lupus erythematosus with pregnancy

Jing Li1, Mei Zhong1()   

  • Received:2019-02-11 Published:2019-05-18
  • Corresponding author: Mei Zhong
引用本文:

汪丽萍, 钟梅. 妊娠合并系统性红斑狼疮的活动期管理[J]. 中华产科急救电子杂志, 2019, 08(02): 82-86.

Jing Li, Mei Zhong. Management of severe systemic lupus erythematosus with pregnancy[J]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2019, 08(02): 82-86.

系统性红斑狼疮(systemic lupus erythematosus, SLE)是好发于育龄期女性的多系统自身免疫性疾病。妊娠可导致SLE由静止期变为活动期,从而增加子痫前期、妊娠丢失、早产、宫内发育迟缓等并发症的发生率,严重影响妊娠结局。本文将重点讨论妊娠合并SLE活动期的识别与管理,以控制病情发展,做到早发现早处理,减少母胎的不良结局。

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that occurs in women of childbearing age. Pregnancy can lead to the change of SLE from quiescent to active, which increases the incidence of complications such as pre-eclampsia, pregnancy loss, premature delivery and intrauterine growth retardation, which seriously affects pregnancy outcomes. This article focus on the identification and management of pregnancy combined SLE activity period, in order to reduce the adverse outcome of the mother and fetus.

表1 妊娠和系统性红斑狼疮的重叠特征[19]
表2 妊娠合并SLE免疫抑制剂的使用[19]
图1 SLE妊娠患者的围产期管理流程[33]
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