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中华产科急救电子杂志 ›› 2020, Vol. 09 ›› Issue (04) : 195 -198. doi: 10.3877/cma.j.issn.2095-3259.2020.04.002

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人类免疫缺陷病毒感染孕妇妊娠晚期快速母婴阻断抗病毒治疗
应若素1, 李芳1,()   
  1. 1. 523000 广州市第八人民医院感染病中心
  • 收稿日期:2020-05-06 出版日期:2020-11-18
  • 通信作者: 李芳
  • 基金资助:
    "十三五"艾滋病和病毒性肝炎等重大传染病防治科技重大专项艾滋病综合治疗方案的优化及推广应用研究(2017ZX10202101-003-001); 2018年度艾滋病和病毒性肝炎等重大传染病防治科技重大专项艾滋病精准诊治标志物的鉴定(2018ZX10302103); 广州市科技计划项目艾滋病功能性治愈新策略-临床与基础研究(201803040002)

Antiviral therapy of rapid blocking mother-to-child transmission of HIV during the third trimester

Ruosu Ying1, fang Li1()   

  • Received:2020-05-06 Published:2020-11-18
  • Corresponding author: fang Li
引用本文:

应若素, 李芳. 人类免疫缺陷病毒感染孕妇妊娠晚期快速母婴阻断抗病毒治疗[J/OL]. 中华产科急救电子杂志, 2020, 09(04): 195-198.

Ruosu Ying, fang Li. Antiviral therapy of rapid blocking mother-to-child transmission of HIV during the third trimester[J/OL]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2020, 09(04): 195-198.

人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染孕妇应尽早使用联合抗病毒治疗阻断HIV母婴传播,抗病毒治疗时间越早、越长,阻断效果越明显。但在临床上常见部分HIV感染孕妇直到妊娠晚期或临产前才来就诊,对这部分患者在保证安全的前提下,如何进行抗病毒治疗快速阻断HIV母婴传播,在选择药物时,除了考虑快速强效抑制病毒,还要注意药物对胎儿的安全性、脐带血药物浓度及新生儿药物洗脱等问题。本文就国内外孕妇感染HIV的现状、HIV母婴阻断用药现状及妊娠晚期HIV母婴阻断常用ARV药物等问题进行讨论。

According to the domestic and foreign guidelines, combining antiretroviral treatment was recommended for the HIV-infected pregnant women to prevent mother to child transmission (PMTCT). As the earlier and longer antiviral treatment, the effects of blocking were more obviously. However, in fact, several HIV-infected pregnant women did not come to hospital until the third trimester of pregnancy or before childbirth. Rapid inhibition of virus, the safety of fetuses, drug concentration in cord blood and neonatal drug elution were crucial for these patients to PMTCT of HIV. We discussed the status of pregnant women with HIV infection in the world, drugs for PMTCT of HIV and the usage of ARV drugs in late trimester, and so on.

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