报道1例华法林相关性胎儿颅内出血，结合文献复习分析其临床表现，以提高临床医生对此病的认识。

回顾性分析2020年香港大学深圳医院收治的1例华法林相关性胎儿颅内出血病例的临床诊治过程，复习在中国期刊全文数据库、万方数据知识服务平台、PubMed数据库建库至2021年4月检索的"华法林相关性胎儿颅内出血"相关文献，分析华法林相关性胎儿颅内出血的临床特点及预后。

(1)病例资料：孕妇为心脏机械瓣膜置换术后妊娠，长期服用华法林治疗，孕29^＋1周超声发现胎儿侧脑室增宽，颅脑磁共振成像诊断胎儿颅内出血，考虑为华法林相关性胎儿颅内出血，孕31^＋1周停用华法林，改为依诺肝素抗凝治疗，超声监测胎儿侧脑室无进行性增宽，孕37^＋4周分娩，随访婴儿至11月龄，存在一侧肢体运动异常。(2)文献复习：检索获中文文献1篇，英文文献7篇，共11例，妊娠结局不良8例，均为诊断较晚或诊断后无临床干预；获较好临床结局的3例分别在诊断后转换抗凝方案或提前分娩。

华法林相关性胎儿颅内出血是妊娠期应用华法林抗凝的罕见胎儿并发症，常常预后不良，对妊娠期使用华法林的孕妇进行个体化管理，精细调节华法林的剂量和超声监测胎儿情况很重要，早期诊断及干预是改变妊娠结局的关键。

To report a case of warfarin-associated fetal intracranial hemorrhage and to analyze relevant clinical manifestations based on a literature review.

This study reported a case of warfarin-associated fetal intracranial hemorrhage who was admitted to Hong Kong University Shenzhen Hospital in 2020. Relevant articles were retrieved from China National Knowledge Infractructure, the Wanfang and the PubMed Database from their release dates to April 2021. Clinical manifestations and prognosis of warfarin-associated fetal intracranial hemorrhage were analyzed and discussed.

(1) Case report: a pregnant woman on long-term warfarin after mechanical heart valve replacement had an ultrasound examination at 29^{+ 1} week of pregnancy showing fetal ventriculomegaly. Fetal MRI showed intracranial hemorrhage. Warfarin was stopped and LMWH started at 31^{+ 1} gestational weeks. There was no progressive dilatation of the fetal lateral ventricles. The baby was delivered at 37^{+ 4} weeks and followed up to 11 months of age with abnormal movement of one limb.(2)Literature review: one Chinese and seven English articles were retrieved, including 11 cases. The 8 cases with poor perinatal outcomes were diagnosed late or had no clinical intervention after diagnosis. Three patients with a change in anticoagulant treatment or delivered early after diagnosis achieved better perinatal outcomes.

Warfarin-associated fetal intracranial hemorrhage is a rare fetal complication caused by warfarin anticoagulation during pregnancy, which often has a poor prognosis. It is important to conduct individualized management for pregnant women taking warfarin during pregnancy, fine-regulate the dose of warfarin and monitor the fetal condition by ultrasound. Early diagnosis and intervention are the key to improve the outcome of pregnancy.