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中华产科急救电子杂志 ›› 2024, Vol. 13 ›› Issue (01) : 1 -5. doi: 10.3877/cma.j.issn.2095-3259.2024.01.001

妊娠合并内分泌疾病

妊娠合并皮质醇增多症的诊治
赵平月1, 樊尚荣1,()   
  1. 1. 518036 深圳,北京大学深圳医院妇产科
  • 收稿日期:2023-07-28 出版日期:2024-02-18
  • 通信作者: 樊尚荣

Diagnosis and treatment of hypercortisolism in pregnancy

Pingyue Zhao, Shangrong Fan()   

  • Received:2023-07-28 Published:2024-02-18
  • Corresponding author: Shangrong Fan
引用本文:

赵平月, 樊尚荣. 妊娠合并皮质醇增多症的诊治[J]. 中华产科急救电子杂志, 2024, 13(01): 1-5.

Pingyue Zhao, Shangrong Fan. Diagnosis and treatment of hypercortisolism in pregnancy[J]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2024, 13(01): 1-5.

妊娠合并皮质醇增多症是一种容易漏诊的内分泌疾病,罕见但危险度很高。产科医生应提高对妊娠合并皮质醇增多症的警惕度,明确区分下丘脑-垂体-肾上腺轴的生理性激活和病理性激活,早期诊断并采取合理的方案对症治疗以提高母胎生存率并改善母胎结局。

Hypercortisolism in pregnancy is a rare but dangerous endocrine disorder that can be easily missed. Obstetricians should raise awareness of Cushing′s syndrome in pregnancy, differentiate between physiological activation and pathological activation of the hypothalamic-pituitary-adrenal axis, and make an early diagnosis to implement appropriate targeted treatments. This approach aims to improve both maternal and fetal outcomes.

图1 皮质醇增多症的诊断流程图注:UFC:(urinary free cortisol)尿游离皮质醇;LNSC:(late-night salivary cortisol)深夜唾液皮质醇;DST:(dexamethasone suppression test)地塞米松抑制试验;MRI:(magnetic resonance imaging)磁共振成像;ACTH:(adrenocorticotrophin hormone)促肾上腺皮质激素;CRH:(corticotrophin releasing hormone)促肾上腺皮质激素释放激素
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