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中华产科急救电子杂志 ›› 2024, Vol. 13 ›› Issue (01) : 60 -63. doi: 10.3877/cma.j.issn.2095-3259.2024.01.011

综述

唇腭裂病因研究进展
胡淼1, 邢丽英1, 张丽姿1, 陈兢思1,()   
  1. 1. 510150 广州医科大学附属第三医院妇产科 广东省产科重大疾病重点实验室 粤港澳母胎医学高校联合实验室 广东省妇产疾病临床医学研究中心
  • 收稿日期:2023-04-12 出版日期:2024-02-18
  • 通信作者: 陈兢思
  • 基金资助:
    国家重点研发计划(2022YFC2704500、2022YFC2704505); 国自然科学基金重点项目(81830045); 广东省自然科学基金(2020A1515012405); 广东省自然科学基金(2022A1515012405); 广州市科技计划市校(院)联合资助项目(202102010005)

Research progress on the etiology of cleft lip and palate

Miao Hu, Liying Xing, Lizi Zhang   

  • Received:2023-04-12 Published:2024-02-18
引用本文:

胡淼, 邢丽英, 张丽姿, 陈兢思. 唇腭裂病因研究进展[J]. 中华产科急救电子杂志, 2024, 13(01): 60-63.

Miao Hu, Liying Xing, Lizi Zhang. Research progress on the etiology of cleft lip and palate[J]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2024, 13(01): 60-63.

唇腭裂是指嘴唇、上颚或两者都没有在中线闭合并保持打开的一类疾病,是影响口腔和面部常见的先天性畸形。唇腭裂从部位上可分为单纯唇裂(cleft lip only, CLO)、唇裂伴腭裂(cleft lip and palate,CLP)和单纯腭裂(cleft palate only,CPO)[1]。唇腭裂可单独发生,也可与其他先天性畸形组合发生,特别是与先天性心脏病一起发生。单独发生的唇腭裂称为非综合型唇腭裂(non-syndromic cleft lip with or without cleft palate,NSCL/P),与其他先天畸形组合发生的唇腭裂称为综合征型唇腭裂(syndromic cleft lip with or without cleft palate,SCL/P)[1]。唇腭裂导致的问题包括哺乳过程困难、发育障碍、语言障碍、耳聋、错颌、严重的面部畸形和严重的心理问题,且治疗过程复杂。因此,加强病因研究,从根本上降低唇腭裂的发病率至关重要。本文将从唇腭裂的病因方面作出综述。

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