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中华产科急救电子杂志 ›› 2026, Vol. 15 ›› Issue (01) : 21 -27. doi: 10.3877/cma.j.issn.2095-3259.2026.01.006

妊娠合并子宫肌瘤

妊娠期子宫肌瘤肉瘤样变性的诊治
范辉健, 刘娟()   
  1. 510150 广州医科大学附属第三医院妇产科 广东省产科重大疾病重点实验室 广东省妇产疾病临床医学研究中心 粤港澳母胎医学高校联合实验室
  • 收稿日期:2025-10-18 出版日期:2026-02-18
  • 通信作者: 刘娟
  • 基金资助:
    广州地区临床特色技术建设项目(2023C-TS42)

Diagnosis and treatment of sarcomatous degeneration of uterine fibroids during pregnancy

Huijian Fan, Juan Liu()   

  • Received:2025-10-18 Published:2026-02-18
  • Corresponding author: Juan Liu
引用本文:

范辉健, 刘娟. 妊娠期子宫肌瘤肉瘤样变性的诊治[J/OL]. 中华产科急救电子杂志, 2026, 15(01): 21-27.

Huijian Fan, Juan Liu. Diagnosis and treatment of sarcomatous degeneration of uterine fibroids during pregnancy[J/OL]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2026, 15(01): 21-27.

子宫肌瘤变性是妊娠合并子宫肌瘤的常见并发症,其中以子宫肌瘤红色样变性为主,妊娠期出现子宫肌瘤肉瘤样变性十分罕见。子宫肌瘤肉瘤样变性恶性程度高,易转移,在妊娠期出现后临床症状不典型,可表现为子宫肿物迅速增大、腹痛及阴道流血,磁共振成像检查是主要的辅助检查方法。尽管流产和早产是妊娠合并子宫肌瘤肉瘤样变性的主要并发症,但大部分孕晚期发现的子宫肌瘤肉瘤样变性患者可获得存活胎儿。孕期诊断子宫肌瘤肉瘤样变性十分困难,往往在剖宫产或分娩后才能确诊,确诊后补充手术进行完整肿瘤切除和补充放化疗是改善母体预后的关键。

Degeneration of uterine fibroids is a frequent complication in pregnancy, with red degeneration being the most prevalent form. In contrast, sarcomatous transformation of uterine fibroids during pregnancy is exceedingly rare. Fibroids exhibiting sarcomatous change are highly malignant and carry a significant risk of metastasis. When such transformation occurs during pregnancy, clinical manifestations are often nonspecific and may include rapid enlargement of the uterine mass, abdominal pain, and vaginal bleeding.Magnetic resonance imaging serves as the primary auxiliary diagnostic tool. Although miscarriage and preterm delivery are major obstetric complications of sarcomatous degeneration, most patients diagnosed in the late third trimester can achieve favorable fetal outcomes. It is very difficult to diagnose sarcomatous transformation of uterine fibroids during pregnancy, and the diagnosis is ofter confirmed only after cesarean section or vaginal delivery. Prompt surgical intervention for complete tumor resection, along with adjuvant radiotherapy or chemotherapy when indicated, is critical to optimizing maternal prognosis.

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