探讨多胎妊娠延迟间隔分娩的围产期管理及母婴结局。

收集2017年至2024年在我院进行延迟间隔分娩的14例多胎妊娠病例，对其分娩孕周、分娩间隔时间、围产期管理、母婴结局进行回顾性分析。

14例患者中，12例为体外受精-胚胎移植受孕，2例为促排卵指导同房受孕，其中双胎妊娠12例，三胎妊娠2例。第一胎平均分娩孕周为21^＋2周，最后一胎延迟间隔分娩平均时限为47.42 d(2~127 d)，分娩平均孕周为28^＋6周。共获13例活婴，出生平均体重为1 531.53 g(800~3 090 g)，其中12例分娩后新生儿即转新生儿重症监护室(neonatal intensive care unit，NICU)，1例出生后3 d因新生儿黄疸转入NICU治疗，NICU平均入住时间45.85 d(1~89 d)。14例患者经阴道分娩12例(其中包含流产3例)，剖宫产术分娩2例。所有患者均给予抗生素预防感染，使用宫缩抑制剂，未行宫颈环扎术；10例患者分娩后胎盘送病理检查，其中发生胎盘早剥1例，8例胎盘病理提示Ⅰ~Ⅱ期绒毛膜羊膜炎，2例胎盘病理未见炎症。

延迟间隔分娩对于多胎妊娠是一种特殊的治疗方法，此方法的成功应用提高了多胎妊娠剩余胎儿的生存率，有效降低了新生儿死亡率，改善了新生儿结局。

To investigate the perinatal management and maternal and neonatal outcomes of 14 cases of delayed interval delivery in multiple pregnancies.

A retrospective analysis was conducted on 14 cases of multiple pregnancies that underwent delayed interval delivery at our hospital from 2017 to 2024. Data collected included gestational age at delivery, delivery interval, perinatal management, and maternal and neonatal outcomes.

Among the 14 cases, 12 were conceived via in vitro fertilization-embryo transfer, and 2 via ovulation induction with timed intercourse. There were 12 twin pregnancies and 2 triplet pregnancies. The mean gestational age at delivery of the first fetus was 21^{+ 2} weeks, the mean delayed interval for the remaining fetus(es) was 47.42 days (2-127 days), and the mean gestational age at delivery of the last fetus(es) was 28^{+ 6} weeks. A total of 13 live infants were delivered, with a mean birth weight of 1 531.53 g (800-3 090 g). Among these, 12 newborns were transferred to the neonatal intensive care unit (NICU) after delivery, and 1 was transferred to the NICU on due to neonatal jaundice three days after birth. The mean length of NICU stay was 45.85 days (1-89 days). There were 12 vaginal deliveries, including 3 miscarriages, and 2 cesarean deliveries. All patients received prophylactic antibiotics and uterine contraction inhibitors; none underwent cervical cerclage. Placental pathology was available for 10 patients, revealing 1 case of placental abruption, 8 cases of stage Ⅰ-Ⅱ chorioamnionitis, and 2 cases with no inflammatory changes.

Delayed interval delivery is a specialized management strategy for multiple pregnancies. Its successful implementation improves the survival rate of the remaining fetus(es), reduces neonatal mortality, and contributes to better neonatal outcomes.