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中华产科急救电子杂志 ›› 2026, Vol. 15 ›› Issue (02) : 84 -88. doi: 10.3877/cma.j.issn.2095-3259.2026.02.004

论著

妊娠合并肿瘤死亡6例临床分析
林丽华1, 林娟2, 颜建英3,()   
  1. 1350001 福州,福建省妇幼保健院保健部 福建医科大学妇儿临床医学院
    2350001 福州,福建省妇幼保健院妇女保健科 福建医科大学妇儿临床医学院
    3350001 福州,福建省妇幼保健院产科 福建医科大学妇儿临床医学院
  • 收稿日期:2025-04-10 出版日期:2026-05-18
  • 通信作者: 颜建英
  • 基金资助:
    2023年福建省卫生健康青年科研课题(2023QNA060)

Maternal death due to malignancy in pregnancy: a clinical analysis of 6 cases

Lihua Lin, Juan Lin, Jianying Yan()   

  1. 1Department of Healthcare, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350001, China
    2Department of Women′s Health Care, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350001, China
    3Department of Obstetrics, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350001, China
  • Received:2025-04-10 Published:2026-05-18
  • Corresponding author: Jianying Yan
引用本文:

林丽华, 林娟, 颜建英. 妊娠合并肿瘤死亡6例临床分析[J/OL]. 中华产科急救电子杂志, 2026, 15(02): 84-88.

Lihua Lin, Juan Lin, Jianying Yan. Maternal death due to malignancy in pregnancy: a clinical analysis of 6 cases[J/OL]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2026, 15(02): 84-88.

目的

探讨妊娠合并肿瘤患者的临床特征、诊断、治疗及其死亡原因。

方法

采用回顾性研究方法对福建省内2021年1月至12月发生死亡的6例妊娠合并肿瘤患者的临床资料进行分析。

结果

6例患者中3例为胃癌,1例为肺腺癌,1例为肺淋巴管平滑肌瘤,1例为横纹肌肉瘤;误诊、漏诊4例(其中1例隐瞒病史、拒绝专科检查),3例发生远处或全身转移,仅1例有条件接受肿瘤治疗,其余均为对症支持治疗;2例采取剖宫产终止妊娠后发生产妇死亡,2例产妇在发生死胎后死亡,余2例为孕期即发生孕妇死亡;6例患者均为肿瘤进展导致死亡。

结论

妊娠合并肿瘤症状隐匿,误诊和漏诊率高,确诊时肿瘤分期晚,进展迅速,患者预后差,临床上需加强多学科协作,通过早诊断、早治疗及个体化决策改善预后。

Objective

To investigate the clinical characteristics, diagnosis, treatment, and causes of death in patients with pregnancy complicated by tumors.

Methods

A retrospective analysis was conducted on the clinical data of 6 maternal death cases involving pregnancy complicated by tumors in Fujian Province from January to December 2021.

Results

Among the 6 cases, three were gastric cancer, one was pulmonary adenocarcinoma, one was pulmonary lymphangioleiomyomatosis, and one was rhabdomyosarcoma. 4 cases were misdiagnosed or missed (including 1 case where the patient concealed her medical history and refused specialized examinations). Distant or systemic metastasis occurred in 3 cases. Only one patient was eligible to receive tumor-specific treatment, while the others received only symptomatic and supportive care. Two maternal deaths occurred after termination of pregnancy by cesarean section, two occurred following intrauterine fetal death, and the remaining two occurred during pregnancy. All six patients died due to tumor progression.

Conclusions

Tumors complicating pregnancy are characterized by insidious symptoms, high rates of misdiagnosis and missed diagnosis, advanced tumor stages at diagnosis, rapid progression, and poor prognosis. In clinical practice, multidisciplinary collaboration should be strengthened to improve outcomes through early diagnosis, timely treatment, and individualized decision-making.

表1 6例妊娠合并肿瘤死亡患者的一般情况
表2 6例妊娠合并肿瘤死亡患者的临床表现、诊断、治疗、妊娠结局及死亡原因
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