Thrombophilia and fetal growth restriction

Zhen Chen; Hongbo Qi

doi:10.3877/cma.j.issn.2095-3259.2023.01.004

Chinese Journal of Obstetric Emergency(Electronic Edition) >

2023 , Vol. 12 >Issue 01: 18 - 21

DOI: https://doi.org/10.3877/cma.j.issn.2095-3259.2023.01.004

Expert Commentary

Thrombophilia and fetal growth restriction

Zhen Chen ,
Hongbo Qi ^,^†

Expand

Received date: 2022-10-13

Online published: 2023-06-06

Copyright

No content published by the journals of Chinese Medical Association may be reproduced or abridged without authorization. Please do not use or copy the layout and design of the journals without permission.

All articles published represent the opinions of the authors, and do not reflect the official policy of the Chinese Medical Association or the Editorial Board, unless this is clearly specified.

Fold

Abstract

Thromboembolism is divided into hereditary thromboembolism and acquired thromboembolism.Hereditary thromboembolism increases the risk of maternal VTE, but most of current studies have shown that there is no clear causal relationship between hereditary thromboembolism and FGR.Acquired thromboembolism (including autoimmune diseases) is more closely related to FGR.The management of pregnancy should be completed by multidisciplinary team cooperation of obstetrics, rheumatology and immunology department, pediatrics and so on.Pregnancy monitoring should be aimed at determining placental insufficiency and fetal growth restriction to determine the optimal timing of delivery and reduce the risk of perinatal morbidity and mortality.

Key words： Venous thromboembolism; Venous thrombosis; Fetal growth retardation; Pregnancy complications

Cite this article

Zhen Chen , Hongbo Qi . Thrombophilia and fetal growth restriction[J]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2023 , 12(01) : 18 -21 . DOI: 10.3877/cma.j.issn.2095-3259.2023.01.004

References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	中华医学会血液学分会血栓与止血学组. 易栓症诊断与防治中国指南(2021年版)[J]. 中华血液学杂志，2021，42(11)：881-888.

[2]	Rodger MA, Paidas M, Mclintock C, et al. Erratum: inherited thrombophilia and pregnancy complications revisited [J]. Obstet Gynecol，2008，112(2 Pt 1)：320-324.

[3]	Facco F, You W, Grobman W. Genetic thrombophilias and intrauterine growth restriction: a meta-analysis [J]. Obstet Gynecol，2009，113(6)：1206-1216.

[4]	Infante-Rivard C, Rivard GE, Yotov WV, et al. Absence of association of thrombophilia polymorphisms with intrauterine growth restriction [J]. N Engl J Med，2002，347(1)：19-25.

[5]	Dizon-Townson D, Miller C, Sibai B, et al. The relationship of the factor V Leiden mutation and pregnancy outcomes for mother and fetus [J]. Obstetrics & Gynecology，2005，106(3)：517-524.

[6]	Said JM, Higgins JR, Moses EK, et al. Inherited thrombophilia polymorphisms and pregnancy outcomes in nulliparous women [J]. Obstetrics & Gynecology，2010，115(1)：5-13.

[7]	Murphy RP, Donoghue C, Nallen RJ, et al. Prospective evaluation of the risk conferred by factor V Leiden and thermolabile methylenetetrahydrofolate reductase polymorphisms in pregnancy [J]. Arterioscler Thromb Vasc Biol，2000，20(1)：266-270.

[8]	Clark P, Walker ID, Govan L, et al. The GOAL study: a prospective examination of the impact of factor V Leiden and ABO (H) blood groups on haemorrhagic and thrombotic pregnancy outcomes [J]. Br J Haematol，2008，140(2)：236-240.

[9]	Lindqvist PG, Svensson PJ, Maršál K, et al. Activated protein C resistance (FV: Q506) and pregnancy [J]. Thromb Haemost，1999，81(4)：532-537.

[10]	Silver RM, Zhao Y, Spong CY, et al. Prothrombin gene G20210A mutation and obstetric complications [J]. Obstetrics and Gynecology，2010，115(1)：1-7.

[11]	Bundhun PK, Soogund MZS, Huang F. Impact of systemic lupus erythematosus on maternal and fetal outcomes following pregnancy: a meta-analysis of studies published between years 2001–2016 [J]．J Autoimmun，2017，79：17-27.

[12]	中华医学会围产医学分会胎儿医学学组，中华医学会妇产科学分会产科学组. 胎儿生长受限专家共识(2019版) [J]．中国产前诊断杂志(电子版)，2019，11(4)：78-98.

[13]	Fetal Growth Restriction: ACOG practice bulletin, number 227 [J]. Obstet Gynecol，2021，137(2)：e16-e28.

[14]	American College of Obstetricians and Gynecologists. ACOG practice bulletin NO.197: inherited thrombophilias in pregnancy [J]. Obstet Gynecol，2018，132(1)：e18-e34.

[15]	Andreoli L, Bertsias GK, Agmon-Levin N, et al. EULAR recommendations for women′s health and the management of family planning, assisted reproduction, pregnancy and menopause in patients with systemic lupus erythematosus and/or antiphospholipid syndrome [J]. Ann Rheum Dis, 2017，76(3)：476-485.

[16]	中华医学会围产医学分会. 产科抗磷脂综合征诊断与处理专家共识[J]. 中华围产医学杂志，2020，23(8)：517-522.

[17]	Rodger MA, Gris JC，De Vries JIP，et al.Low-molecular-weight heparin and recurrent placenta-mediated pregnancy complications: a meta-analysis of individual patient data from randomised controlled trials[J]．Lancet，2016，388(10060)：2629-2641

[18]	Mastrolia SA, Novack L, Thachil J, et al. LMWH in the prevention of preeclampsia and fetal growth restriction in women without thrombophilia [J]. Thromb Haemost，2016，116(11)：868-878.

Options

Outlines

模态框（Modal）标题

Abstract

Cite this article

References