探讨新疆维吾尔族(简称维族)和哈萨克族(简称哈族)孕妇早发型子痫前期(E-PE)器官受累特点与围产结局的关系。

对2009年1月至2010年12月新疆伊宁市伊犁州友谊医院收治的297例E-PE患者进行回顾性分析，以民族不同分为维族(145例)和哈族(152例)，比较两组一般临床资料，器官受累情况以及围产结局。定量资料采用t检验，定性资料采用卡方检验。

297例E-PE患者中，两个民族均以单器官受累为主，维族患者以胎盘(26/61，42.6%)、肾脏(17/61，27.9%)损害为主，哈族以胎盘(24/65，37.1%)、脑(15/65，23.1%)、心脏(12/65，18.5%)损害为主。在两器官受累中，维族以胎盘并肾损害(15/24，62.5%)为主，哈族以胎盘并子痫(9/25，36.0%)及胎盘并脑病(12/25，48.0%)为主。器官受累者中，维族患者胎儿及新生儿死亡率为44.4%(40/90)，哈族为46.9%(46/98)，差异无统计学意义(χ²＝0.118，P>0.05)。

E-PE孕产妇器官受累情况在维族、哈族之间存在差异，围产儿死亡率在两民族之间差异无统计学意义。

To analyze association between organ damage and pregnancy outcome of early-onset preeclampsia (E-PE) patients, who were Uigur or Kazak in Xinjiang.

This retrospective study of 297 E-PE pregnant women including 145 Uigur and 152 Kazak patients from Jan. 2009 to Dec. 2010 in Yili State Youyi Hospital was done. The clinical data were recorded and comparisons on organ damage and pregnancy outcome were analyzed. We used t test to compare the quantitative data, Chi-Square test to compare qualitative data.

The study revealed that patients were mainly with one organ damage. Patients with placenta or renal damage were the most common in Uigur (26/61, 42.6% and 17/61, 27.9%, respectively), while patients with placenta, heart or brain damage were most common in Kazak (24/65, 37.1%, 15/65, 23.1% and 12/65, 18.5%, respectively). If patients with two organs damage, Uigur patients were primarily with placenta and renal damage(15/24, 62.5%), Kazak patients were most common with placenta damage and eclampsia (9/25, 36.0%) or brain damage (12/25, 48.0%). The perinatal mortality showd no significant difference in Uigur and Kazak groups [44.4%(40/90) vs 46.9%(46/98), χ²=0.118, P>0.05].

It shows significant difference of organ damage in early-onset preeclampsia patients who are Uigur and Kazak nationality. But the perinatal mortality shows no significant difference between the two groups.