探讨妊娠合并白血病的诊断、处理及预后。

对2010年1月至2015年10月广州医科大学附属第三医院收治的11例妊娠合并白血病患者的临床资料进行回顾性分析，分析患者的临床表现、实验室检查、处理方式和随访结果。

11例病例中，3例无临床症状，8例表现为典型或不典型症状。11例血常规均异常，骨髓活检确诊为白血病，其中8例为急性白血病，3例慢性粒细胞白血病。6例急性白血病接受化疗，5例存活，1例产后2个月死亡；2例急性白血病患者拒绝化疗后死亡。3例慢性粒细胞白血病患者均接受了化疗，均完全缓解。随访结果：7例患者存活，1例失访；新生儿存活8例。

妊娠合并白血病罕见，其症状与妊娠相似，不易及时确诊，处理方式应根据白血病类型、孕龄、孕妇及胎儿状况综合考虑。

To investigate the diagnosis, treatment and prognosis of leukemia during pregnancy.

We retrospectively analyzed the clinical data of 11 cases of leukemia during pregnancy in the Third Affiliated Hospital of Guangzhou Medical University from January 2010 to October 2015. Clinical data included clinical manifestation, laboratory examination, management and follow-up outcome.

Of 11 cases, 3 cases presented without any clinical symptoms, 8 cases presented with typical or atypical clinical symptoms. Blood routine tests were found abnormal in all 11 cases and were diagnosed as leukemia by bone marrow biopsy. Eight cases were diagnosed as acute leukemia and 3 cases were chronic myeloid leukemia. In six patients with acute leukemia received chemotherapy, 5 patients were alive, 1 patient died two month later after delivery. Two patients with acute leukemia refused chemotherapy and died. All the 3 patients with chronic myelocytic leukemia underwent chemotherapy and then were alive. The results of follow-up were that 7 patients were alive, 1 case was lost of follow-up, and all of 5 newborns were alive.

Leukemia during pregnancy was rare, the diagnosis of leukemia during pregnancy was often delayed due to the symptom similarity to those of pregnancy. The treatment of leukemia during pregnancy should be made according to the different type of leukemia, gestational age, pregnant women and fetal conditions.