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中华产科急救电子杂志 ›› 2022, Vol. 11 ›› Issue (04) : 241 -245. doi: 10.3877/cma.j.issn.2095-3259.2022.04.010

病例报告

妊娠合并系统性红斑狼疮伴发神经精神狼疮一例
梁伟璋1, 李佳1, 贺芳1,()   
  1. 1. 510150 广州医科大学附属第三医院妇产科 广州重症孕产妇救治中心 广东省产科重大疾病重点实验室
  • 收稿日期:2022-08-15 出版日期:2022-11-18
  • 通信作者: 贺芳
  • 基金资助:
    广东省基础与应用基础研究基金区域联合基金项目(2021B1515120070); 广州市校联合资助(高水平大学)基础研究项目(202102010131)

A case of pregnancy complicated with neuropsychiatric systemic lupus erythematosus

Weizhang Liang1, Jia Li1, Fang He1()   

  • Received:2022-08-15 Published:2022-11-18
  • Corresponding author: Fang He
引用本文:

梁伟璋, 李佳, 贺芳. 妊娠合并系统性红斑狼疮伴发神经精神狼疮一例[J]. 中华产科急救电子杂志, 2022, 11(04): 241-245.

Weizhang Liang, Jia Li, Fang He. A case of pregnancy complicated with neuropsychiatric systemic lupus erythematosus[J]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2022, 11(04): 241-245.

患者22岁,孕1产0,因"停经27+3周,抽搐伴意识丧失9个多小时"于2021年7月13日12:05自外院转入广州医科大学附属第三医院产科。患者既往体健,否认高血压、糖尿病及肝病病史,平素月经规律,末次月经2021年1月2日,预产期2021年10月9日。自然受孕,孕11+周在外院建册并产前检查(产检),建册时血压83/54 mmHg(1 mmHg=0.133 kPa),共产检6次,产检血压在103-116/57-72 mmHg之间。孕期超声测量颈项透明层、唐氏筛查、Ⅲ级超声和口服葡萄糖糖耐量试验(oral glucose tolerance test,OGTT)均无异常。4月中旬(孕14+周)无明显诱因出现双手掌红斑疹伴痒痛,在外院皮肤科就诊,使用外用药效果欠佳。6月23日(孕23+周)产检时发现尿蛋白(+),6月30日就诊内科,查抗核抗体(+),核酸颗粒型1∶1000,胞浆颗粒型1∶1000,补体C4 0.139 g/L,抗SSA抗体>400 RU/ml,抗SSB抗体102.64 RU/ml。患者未予特殊重视。2021年7月9日(孕26+周)出现双下肢浮肿,血压升高(141/89 mmHg),查尿蛋白(++++),考虑不排除系统性红斑狼疮(systemic lupus erythematosus, SLE),建议到风湿免疫科治疗。7月10日患者外院风湿免疫科就诊,测血压仍高,诊断"SLE",收其入院,但患者未遵嘱住院自行回家。11日出现头痛,以左后脑部为主,伴有睡眠欠佳,12日住院治疗。查血常规发现血小板下降:白细胞12.58×109/L,血红蛋白103 g/L,红细胞3.10×1012/L,红细胞比容30.7%,血小板74×109/L。12日22:00患者出现头晕、头痛伴视物模糊,但未告知值班医生;13日凌晨03:00邻床病人发现患者先后抽搐3次,但未报告值班医护人员;至清晨07:00查房时发现患者神志不清,立即呼叫二线值班医生,同时给予吸氧,心电监护,查血气组合等对症处理。08:30再次出现抽搐伴意识障碍,牙关紧闭,四肢屈曲,无角弓反张及大小便失禁,测血压142/93 mmHg,后血压持续增高,达173/110 mmHg,考虑"子痫",给予乌拉地尔降压及硫酸镁解痉治疗。因病情危重,为进一步治疗转至我院。

图1 妊娠合并系统性红斑狼疮患者产后1天复查头颅MRA影像图。A:T2加权成像示双侧基底节、丘脑、颞枕叶区呈多发片状高信号(红色箭头所示); B:病灶的液体衰减反转恢复序列(FLAIR)呈高信号(红色箭头所示)
图2 妊娠合并系统性红斑狼疮患者产后复查头颅MRA对比图像。A:7月14日MRA示脑内动脉管腔粗细不均匀,呈串珠样(红色箭头所示);B:7月28日MRA示原血管串珠样改变已经消失(红色箭头所示)
图3 妊娠合并系统性红斑狼疮患者产后2周复查头颅MR影像图。A:T2加权成像示原双侧基底节、丘脑、颞枕叶区的多发片状高信号已经消失(红色箭头所示) ;B:原病灶的液体衰减反转恢复序列高信号已经消失(红色箭头所示)
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