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中华产科急救电子杂志 ›› 2023, Vol. 12 ›› Issue (01) : 6 -11. doi: 10.3877/cma.j.issn.2095-3259.2023.01.002

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易栓症和子痫前期
贺芳()   
  1. 510150 广州医科大学附属第三医院妇产科 广东省产科重大疾病重点实验室 广州重症孕产妇救治中心
  • 收稿日期:2022-11-05 出版日期:2023-02-18
  • 通信作者: 贺芳
  • 基金资助:
    广东省基础与应用基础研究基金区域联合基金项目(2021B1515120070)

Thrombophilia and preeclampsia

Fang He()   

  • Received:2022-11-05 Published:2023-02-18
  • Corresponding author: Fang He
引用本文:

贺芳. 易栓症和子痫前期[J/OL]. 中华产科急救电子杂志, 2023, 12(01): 6-11.

Fang He. Thrombophilia and preeclampsia[J/OL]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2023, 12(01): 6-11.

近年来,易栓症和不良妊娠结局的关系越来越引起人们的重视。易栓症是指因各种遗传性或获得性因素导致的容易发生血栓形成和血栓栓塞的病理状态。子痫前期是妊娠期或产后发生静脉血栓栓塞的独立危险因素,若同时患有易栓症,更是放大了孕期生理性高凝状态这一特殊时期的血栓风险。但总的来说,遗传性易栓症不是导致流产和其他并发症(包括子痫前期、胎儿生长受限和胎盘早剥)的主要因素,至多是导致这些并发症的遗传和环境诱因之一,而获得性易栓症(如抗磷脂综合征)则与具有"严重症状"的子痫前期相关。

In recent years, the relationship between thrombophilia and adverse pregnancy outcomes has attracted more and more attention.Thrombophilia refers to a pathological state in which thrombosis and thromboembolism is prone to occur due to various genetic or acquired factors.It is generally believed that the pathogenesis of hypertensive disorders in pregnancy is the damage of systemic vascular endothelial cells. If thrombophilia is present at the same time, the risk of thrombosis in the special period of physiological hypercoagulable state during pregnancy will be amplified.However, it is unlikely that hereditary thrombophilias are a major factor in miscarriage and other adverse pregnancy outcomes including preeclampsia, fetal growth restriction, and placental abruption, as most thrombosis due to hereditary thrombophilias isone of many well-known genetic and environmental predispositions to these complications and acquired thrombophilia antiphospholipid syndrome is associated with severe features of preeclampsia.

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