结合目前我国流行的奥密克戎变异株背景，研究奥密克戎变异株在妊娠女性中发病的临床特征。

通过问卷调查结合采集门诊及住院患者病历信息方式，收集2022年12月至2023年1月在广州医科大学附属第三医院诊疗的249例妊娠合并新冠病毒感染患者的病历资料并进行回顾性分析，总结其临床特征。

249例患者年龄为22~45岁，发病集中在12月中旬，与国内发病高峰期基本吻合；孕早、中及晚期发病者分别为23(9.24%)、93(37.35%)、129(51.81%)例，其中4例孕周数据缺失。无症状患者10例，轻中型234例(93.98%)，重型4例(1.61%)，危重型1例(0.40%)。常见的临床症状为发热(74.5%)、鼻塞(68.2%)、咳嗽68.2%)、咽痛(52.3%)和全身肌肉酸痛(49.8%)。孕早、中、晚期发热峰值分别为(38.60±0.87)℃、(38.43±0.57)℃和(38.39±0.59)℃，差异无统计学意义。孕早期发热持续时间[(2.17±0.96)d]，与孕中期[(1.61±0.10)d]比较差异有统计学意义(P＝0.034)，与孕晚期[(1.73±0.10)d]比较差异无统计学意义。73.90%的患者症状可自行缓解，2.01%的患者需重症监护。

妊娠合并奥密克戎变异株感染患者绝大多数为轻中型患者，重型、危重型较少见；临床上以发热、咳嗽、鼻塞、咽痛以及肌肉酸痛等症状最为常见；孕早期平均发热时间较孕中晚期长。

To study the manifestations of pregnant patients with novel coronavirus omicron variant infection according to the background of Omicron variant strains currently prevalent in China.

The clinical data of 249 pregnant patients with novel coronavirus infection (COVID-19) in the Third Affiliated Hospital of Guangzhou Medical University from December 2022 to January 2023 were collected through questionnaire survey and analyzed retrospectively to summarize their clinical characteristics.

The age of 249 patients ranges from 22 to 45 years old, the onset of 249 patients in our hospital was concentrated in mid-December, which coincided with the peak period of the domestic epidemic period. 23(9.24%), 93(37.35%), and 129(51.81%) cases were onset in the early, middle and late pregnancy, respectively. The data for gestational weeks was absent in 4 cases. Among the 249 cases, there were 10 asymptomatic patients, 234(93.98%) mild or moderate patients, 4(1.61%) severe patients, and 1(0.40%) critical patient. The most common clinical symptoms were fever (74.5%), nasal congestion (68.2%), cough (68.2%), sore throat (52.3%) and general muscle aches (49.8%). The peak fevers in the first, middle and late stages of pregnancy were (38.60±0.87) ℃, (38.43±0.57) ℃ and (38.39±0.59) ℃, respectively, with no statistical difference. The duration of fever in the first trimester (2.17±0.96) days was significantly different from that in the second trimester (1.61±0.10) days (P=0.034), but not from that in the third trimester (1.73±0.10) days. 73.90% of the patient′s symptoms could be relieved by themselves, and 2.01% of the patients required intensive care.

Most of the pregnant patients with Omicron variants are mild to moderate, and severe and critical are rare. Clinically, symptoms such as fever, cough, nasal congestion, sore throat, and muscle aches are the most common symptoms. The average duration of fever in the first trimester is often longer than that in the second and third trimesters.