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中华产科急救电子杂志 ›› 2023, Vol. 12 ›› Issue (02) : 123 -127. doi: 10.3877/cma.j.issn.2095-3259.2023.02.013

综述

粒细胞集落刺激因子治疗复发性流产的研究进展
祝丽琼, 张建平()   
  1. 510120 广州,中山大学孙逸仙纪念医院妇产科
  • 收稿日期:2022-12-26 出版日期:2023-05-18
  • 通信作者: 张建平
  • 基金资助:
    国家重点研发项目(2019YFA0801403)

Research progress of granulocyte colony-stimulating factor in the treatment of recurrent spontaneous abortion

Liqiong Zhu, Jianping Zhang()   

  • Received:2022-12-26 Published:2023-05-18
  • Corresponding author: Jianping Zhang
引用本文:

祝丽琼, 张建平. 粒细胞集落刺激因子治疗复发性流产的研究进展[J]. 中华产科急救电子杂志, 2023, 12(02): 123-127.

Liqiong Zhu, Jianping Zhang. Research progress of granulocyte colony-stimulating factor in the treatment of recurrent spontaneous abortion[J]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2023, 12(02): 123-127.

复发性流产(recurrent spontaneous abortion, RSA),也叫反复妊娠丢失,是指与同一性伴侣,妊娠28周内3次或3次以上的妊娠丢失[1]。但目前大多数专家认为,连续发生2次流产的患者,其发生再次流产的风险与3次相近,应予以重视,该观点与欧洲人类生殖与胚胎学会和美国生殖医学学会一致[2,3]。临床上,发生2次或2次以上流产的患者约占生育期妇女的5%,而3次或3次以上者约占1%[3]。RSA的复发风险随着流产次数的增加而上升,研究表明,曾有3次以上连续自然流产史的患者再次妊娠后胚胎丢失率接近40%[1]

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