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中华产科急救电子杂志 ›› 2023, Vol. 12 ›› Issue (03) : 180 -186. doi: 10.3877/cma.j.issn.2095-3259.2023.03.012

论著

胎盘植入性疾病患者行子宫部分切除术后再次妊娠的临床研究
吴文诗, 魏宋荃, 李桂民, 郑晓芳, 孙雯, 陈敦金, 余琳()   
  1. 深圳市中西医结合医院产科,深圳 518104
    广州医科大学附属第三医院妇产科 广东省产科重大疾病重点实验室 广州重症孕产妇救治中心,广州 510150
  • 收稿日期:2023-01-03 出版日期:2023-08-18
  • 通信作者: 余琳
  • 基金资助:
    国家重点研发计划"生育健康及妇女儿童健康保障"重点专项项目(2022YFC2704500); 广州市科创委一般项目(202201010907); 广州市卫生和计划生育委员会一般引导项目(20231A011094)

Outcomes of subsequent pregnancies after partial hysterectomy for placenta accreta spectrum

Wenshi Wu, Songquan Wei, Guimin Li, Xiaofang Zheng, Wen Sun, Dunjin Chen, Lin Yu()   

  1. Department of Obstetrics, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen 518104, China
    Department of Obstetrics and Gynecology, The Third Affiliated of Guangzhou Medical University, Key Laboratory for Major Obstetrics Diseases of Guangdong Province, Guangzhou Medical Center for Critical Pregnant Women, Guangzhou 510150, China
  • Received:2023-01-03 Published:2023-08-18
  • Corresponding author: Lin Yu
引用本文:

吴文诗, 魏宋荃, 李桂民, 郑晓芳, 孙雯, 陈敦金, 余琳. 胎盘植入性疾病患者行子宫部分切除术后再次妊娠的临床研究[J]. 中华产科急救电子杂志, 2023, 12(03): 180-186.

Wenshi Wu, Songquan Wei, Guimin Li, Xiaofang Zheng, Wen Sun, Dunjin Chen, Lin Yu. Outcomes of subsequent pregnancies after partial hysterectomy for placenta accreta spectrum[J]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2023, 12(03): 180-186.

目的

探讨胎盘植入性疾病患者子宫部分切除术后再次妊娠孕期及分娩的风险因素及管理方案。

方法

回顾性分析2015年1月1日至2018年12月31日于广州医科大学附属第三医院因胎盘植入行子宫部分切除术后再次妊娠的12例患者前置胎盘和(或)胎盘植入复发率、术中出血情况、子宫情况、终止妊娠周数、合并症和并发症情况、分娩方式、新生儿情况及产褥期恢复等因素。

结果

(1)12例再次妊娠病例中,1例发生瘢痕处妊娠,其余11例均为宫内妊娠;除1例出现胚胎停育外,余11例早期胚胎发育均良好(含瘢痕处妊娠),未出现胚胎发育不良。(2)12例患者中早孕人工流产4例(终止妊娠孕周为孕6~8周),中孕引产1例(终止妊娠孕周为孕13+周)。(3)活产7例(分娩孕周为孕36~38周)分娩方式为剖宫产,其中中央型前置胎盘合并胎盘植入1例行全子宫切除术,以上手术均术程顺利,血流动力学基本稳定,术后未转重症监护室,活产者新生儿无明显异常,患者术后恢复良好。

结论

(1)胎盘植入性疾病行子宫部分切除术保留生育功能者,再次妊娠有机会正常孕育至分娩。(2)行子宫部分切除术后的再次妊娠存在瘢痕妊娠、胎盘异常及子宫破裂的风险,孕期建议在医生严密观察下继续妊娠及分娩。

Objective

To explore the risk and management approach of re-pregnancy and delivery after partial hysterectomy.

Methods

Retrospective analysis was made on the patients who underwent partial hysterectomy to retain the uterus for PAS in the Third Affiliated Hospital of Guangzhou Medical University from January 1, 2015 to December 31, 2018.Following up the pregnancy process and outcomes of 12 re-pregnancy cases after the operation, the recurrence of placenta previa and/or PAS, intraoperative blood loss, uterine condition, delivery gestational weeks, complications, delivery mode, neonatal condition and puerperal recovery of these cases were analyzed.

Results

1.Among the 12 cases, there are 1 scar pregnancy and 11 intrauterine pregnancies.Most of them had a good early embryo development(including 1 scar pregnancy) except for 1 embryo damage, and there was no embryonic dysplasia.2.Four women chose induced abortion at the first trimester(terminated at 6-8 gestational weeks, including 1 case of scar pregnancy). One woman chose induced labor in the second trimester (terminated at 13+ weeks).3.There were 7 live births (delivered at 36-38 gestational weeks, the mode of delivery was cesarean section, among which 1 case of central placenta previa combined with placenta increta underwent total hysterectomy). All the above operations were successful, the hemodynamics were stable, and no one was transferred to the ICU afterward. There was no obvious abnormality in their newborns, and the postoperative recovery was good.

Conclusions

1.Women with PAS who underwent partial hysterectomy to preserve their reproductive function can have a chance of normal pregnancy afterward. 2.There are risks of scar pregnancy, placental abnormities and uterine rupture in the pregnancies after partial hysterectomy. If these pregnancies were to continue, they should undergo close observation by doctors during the entire gestation and delivery.

表1 12例因胎盘植入性疾病行子宫部分切除手术孕妇的一般情况
表2 12例PAS患者行子宫部分切除的手术原因及手术情况
病例序号 诊断 终止妊娠孕周(周) 子宫部分切除的部位 部分子宫切除大小(cm×cm×cm) 是否阻断子宫动脉 术中生命体征 手术时长(min) 手术出血(ml) 输血情况 术前血红蛋白(g/L) 术后血红蛋白(g/L) 术后转重症监护室
1 胎盘植入 30+ 右宫角 5.5×3×1 平稳 84 300 92 92
2 穿透性胎盘植入,前置胎盘 31 前壁下段 18.5×16×3 平稳 115 2600 红细胞8 U血浆600 ml 110 80
3 胎盘植入,瘢痕妊娠 11 前壁 3×2.5×1 平稳 135 50 110 110
4 胎盘植入,前置胎盘,子宫不完全破裂,失血性休克 34+ 前壁下段 4×3×1 失血性休克 155 2500 红细胞12 U血浆1200 ml 82 85
5 穿透性胎盘植入,前置胎盘 27+ 前壁下段 4×4×1 平稳 188 2000 红细胞4 U 109 68
6 穿透性胎盘植入,前置胎盘 37+ 前壁下段 8×2.5×1 平稳 120 800 术前输红细胞2 U 86 89
7 胎盘植入,失血性休克 20+ 前壁 4×4×1 失血性休克 114 3100 红细胞14 U血浆1000 ml 111 109
8 胎盘植入 20+ 前壁 4.5×3×0.5 平稳 121 300 122 90
9 胎盘植入,前置胎盘 37+ 前壁下段 11×3×1 平稳 171 2000 红细胞4 U血浆200 ml 114 90
10 胎盘植入,前置胎盘 35+ 前壁下段 5×2×2 平稳 170 900 红细胞2 U 103 95
11 胎盘植入,前置胎盘 35+ 子宫下段 20×10×1 平稳 135 2200 红细胞4 U 89 80
12 胎盘植入,前置胎盘 38+ 前壁下段 5×3.5×1.5 平稳 145 400 101 99
表3 12例因PAS行子宫部分切除手术孕妇本次妊娠情况
病例序号 诊断 早期胚胎发育 终止妊娠孕周(周) 终止妊娠方式 子宫形态(超声/术中) 是否阻断子宫动脉 产时出血(ml) 是否行子宫切除 输血情况 术中生命体征 是否转重症监护室 胎儿/新生儿情况
1 正常宫内妊娠 正常 7+ 药物流产 超声子宫形态正常 20 平稳 流产
2 瘢痕妊娠 正常 8 人工流产 超声子宫浆膜完整,绒毛膜植入子宫前壁下段瘢痕 10 平稳 流产
3 正常宫内妊娠 正常 38+ 剖宫产 术中子宫形态正常 200 平稳 正常
4 胎盘植入, 前置胎盘 正常 36+ 剖宫产 术中见广泛粘连,盆腔封闭,子宫下段向外膨隆,呈紫蓝色,表面见异型血管增生 3800 红细胞16 U血浆1000 ml冷沉淀6 U 平稳 正常
5 正常宫内妊娠 正常 38+ 剖宫产 术中前壁及下段与前腹壁、大网膜致密粘连,下段形成差,子宫形态正常 400 平稳 正常
6 正常宫内妊娠 正常 36+ 剖宫产 术中于子宫下段及宫体上部分别见横行疤痕,此处肌层薄 500 平稳 正常
7 稽留流产, 宫腔粘连 胚胎停育 7+ 药物流产+宫腔镜 超声子宫形态正常,宫腔镜左侧宫腔內聚,见纤维粘连带连接前后壁 10 平稳 流产
8 正常宫内妊娠 正常 6 人工流产 超声子宫形态正常 10 平稳 流产
9 正常宫内妊娠 正常 38 剖宫产 术中子宫形态正常 200 平稳 正常
10 正常宫内妊娠 正常 37 剖宫产 术中子宫形态正常 300 平稳 正常
11 正常宫内妊娠 正常 37+ 剖宫产 术中子宫形态正常 300 平稳 正常
12 正常宫内妊娠,子宫不完全破裂 正常 13+ 中孕引产+剖宫取胎 术中见子宫下段与膀胱交界处肌层缺失4*2 cm,仅存浆膜层 1150 红细胞2 U血浆400 ml 平稳 流产
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