2021 , Vol. 10 >Issue 02: 96 - 100
DOI: https://doi.org/10.3877/cma.j.issn.2095-3259.2021.02.007
早发型与晚发型子痫前期的临床特点及母儿结局分析
收稿日期: 2021-01-18
网络出版日期: 2021-07-14
基金资助
国家自然科学基金(81830045); 国家重点研发计划资助(2016YFC1000405和2017YFC1001402); 广东省自然科学基金(2021A1515011039)
The clinical characteristics and maternal and neonatal outcomes of early and late onset preeclampsia
Received date: 2021-01-18
Online published: 2021-07-14
分析早发型与晚发型子痫前期的临床特征及母儿结局。
收集2015年1月至2020年12月6年间在广州医科大学附属第三医院分娩的诊断为子痫前期的单胎孕产妇2693例的临床资料，采用回顾性研究方法分析早发型(873例)与晚发型子痫前期孕妇(1820例)的临床特征及母儿结局。
早发型和晚发型子痫前期患者孕次比较[(2.68±1.58)次与(2.27±1.38)次，Z＝-6.80，(P<0.05)]，转诊患者比例(42% vs 6.3%, χ2＝519.02，P<0.05)，合并慢性高血压比例(2.4% vs 0.8%, χ2＝12.31，P<0.05)，剖宫产率(77.8% vs 60.1%, χ2＝82.35，P<0.05)，胎盘早剥率(0.9% vs 0.3%, χ2＝3.93，P<0.05)，重症监护病房入住率(9.7% vs 2.4%, χ2＝69.3，P<0.05)，住院天数(9.44±4.76)d与(6.30±5.15)d，Z＝-20.52，(P<0.05)，死胎发生率(22.3% vs 0.3%, χ2＝381.1，P<0.05)。
早发型子痫前期与晚发型子痫前期患者临床特点不同，母儿围产期结局不同，两种子痫前期类型应被区分对待。
毕石磊 , 张丽姿 , 杜丽丽 , 陈敦金 . 早发型与晚发型子痫前期的临床特点及母儿结局分析[J]. 中华产科急救电子杂志, 2021 , 10(02) : 96 -100 . DOI: 10.3877/cma.j.issn.2095-3259.2021.02.007
To analyze the clinical characteristics and maternal and perinatal outcomes of early and late onset preeclampsia.
2693 pregnant women with preeclampsia who delivered in the Third Affiliated Hospital of Guangzhou Medical University from 2015 to 2020 were recruited. The clinical characteristics and maternal and neonatal outcomes of early onset (873 cases) and late onset preeclampsia (1820 cases) were analyzed.
The gravidity(2.68±1.58 vs 2.27±1.38, Z=-6.80, P<0.05), patients referred to hospital(42% vs 6.3%, χ2=519.02, P<0.05), and patients with chronic hypertension(2.4% vs 0.8%, χ2=12.31, P<0.05) were higher in the early onset preeclampsia group than the late onset preeclampsia group (P<0.05). The rate of cesarean section(77.8% vs 60.1%, χ2=82.35, P<0.05), placental abruption(0.9% vs 0.3%, χ2=3.93, P<0.05), admission to ICU(9.7% vs 2.4%, χ2=69.3, P<0.05) and hospitalization days [(9.44±4.76) vs (6.30±5.15), Z=-20.52, P<0.05] were significantly higher in the early onset preeclampsia group. The incidence of stillbirth(22.3% vs 0.8%, χ2=381.1, P<0.05) and neonatal death was higher in the early onset preeclampsia than the late onset preeclampsia group.
The clinical characteristics, maternal and perinatal outcomes of patients complicated with early onset preeclampsia and late onset preeclampsia are different. From the perspective of clinical characteristics, maternal and perinatal outcomes, the two types of preeclampsia should be treated differently.
Key words： Pre-eclampsia; Pregnant women; Pregnancy outcome
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