To evaluate the curative effect and safety of domestic Carboprost Tromethamine (trade name: An Lie ke) on preventing intraoperative hemorrhage and postoperative hemorrhage of high risk pregnant women with cesarean section.

Three hundred and sixty pregnant women, who were admitted into 9 hospitals of Guangdong province from March to December 2011, had cesarean section due to bleeding high risk factors. According to the oxytocic drugs injected in the uterine body after delivery, 360 pregnant women were divided into 3 groups: group A (only injected oxytocin), group B (injected oxytocin plus Carboprost Tromethamine) and group C (only injected Carboprost Tromethamine). There were 120 patients in each group. The amount of bleeding was observed during operation, 2 hours after operation and 24 hours after operation, respectively. The amount of bleeding in each observation time and oxytocic drug side effects of the 3 groups were compared.

In group B, the amount of bleeding were (331.4±209.7)ml, (421.8±239.2)ml and (593.6±242.3)ml during operation, 2 hours after operation and 24 hours after operation, respectively, which were significantly less than those in group A[(417.3±235.2)ml, (613.4±301.9)ml and (685.7±296.1)ml] (P<0.05). In group C, the amount of bleeding were (352.5±253.4)ml, (479.4±201.7)ml and (607.1±246.6)ml during operation, 2 hours after operation and 24 hours after operation, respectively, which were also significantly less than those in group A (P<0.05). But there was no significant difference between group B and group C (P>0.05). Totally, 42 cases of 360 cases were postpartum hemorrhage, which incidence rate was 11.7%. The incidence rate of postpartum hemorrhage in group A (18.3%, 22/120) was significantly higher than that in group B(7.5%, 9/120) and group C(9.2%, 11/120), ( χ²=6.145 and 3.596, P value<0.05). The usage rate of extra oxytocic drugs was 11.1% (1/9) in group B and 18.2% (2/11) in group C, which were significantly lower than that in group A (68.2%, 15/22), ( χ²=10.190 and 8.164, P value<0.05). Among the 360 patients, 27 patients had 1 or more adverse reactions; the incidence rate was 7.5%. The incidence rate of adverse reaction in group B (12.5%, 15/120) was higher than those in group A (3.3%, 4/120) and in group C(6.7%, 8/120), ( χ²=12.451 and 9.254, P value<0.05). But the incidence rate of each side reaction had no significant difference in the 3 groups (P value>0.05).

Domestic Carboprost Tromethamine was effective and safe for high risk pregnant women with cesarean section to prevent intraoperative hemorrhage and postoperative hemorrhage. But the side effects need to be closely observed.