Analysis of risk factors of preeclampsia with serious complications

doi:10.3877/cma.j.issn.2095-3259.2015.04.007

Abstract

Abstract:

Objective

To explore the risk factors of preeclampsia with serious complications.

Methods

Clinical data of 805 preeclampsia patients and the perinatal infants were retrospective analyzed. Three hundred and twenty-seven cases with serious complications were in the research group, 478 cases without serious complications were in the control group.

Results

(1) The incidence of preeclampsia patients with serious complications was 40.6%(327/805 cases). The serious complications of 327 cases were including fetal death (138 cases, 42.2%), HELLP syndrome(71 cases, 21.7%), placental abruption(65 cases, 19.9%), cardiac failure(39 cases, 11.9%), postpartum hemorrhage(39 cases, 11.9%), pneumonedema(36 cases, 11.0%) and so on. (2) The clinical manifestation of the two groups, including onset gestational age, systolic pressure, diastolic pressure, creatinine, alanine aminotransferase, albumin and expecting treatment time had statistical significance, P<0.05. (3) In multivariate logistic regression analysis, the risk factors of preeclampsia serious complications were the gestational age of early onset (OR=0.783, 95%CI: 0.745-0.823), high serum creatinine (OR=1.005, 95%CI: 1.001-1.008), hypoproteinemia (OR=0.961, 95%CI: 0.929-0.994).

Conclusion

The risk factors of preeclampsia with serious complications were the gestational age of early onse, kidney function damage and hypoproteinemia.

Key words: Pre-eclampsia, Pregnancy complications, Risk factors

Jingjin Gong, Shiliang Liu, DunJin Chen, Fang He, Wenting Tang. Analysis of risk factors of preeclampsia with serious complications[J]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2015, 04(04): 225-229.

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Figures/Tables 5

References 12

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严重并发症	例数	百分率(%)
死胎	138	42.2
HELLP综合征	71	21.7
胎盘早剥	65	19.9
心功能衰竭	39	11.9
产后出血	39	11.9
肺水肿	36	11.0
子痫	11	3.4
血小板减少	7	2.1
肾功能衰竭	6	1.8
脑水肿	4	1.2
视网膜脱落	3	0.9
呼吸衰竭	2	0.6
产妇死亡	1	0.3

严重并发症	例数	百分率(%)
死胎	138	42.2
HELLP综合征	71	21.7
胎盘早剥	65	19.9
心功能衰竭	39	11.9
产后出血	39	11.9
肺水肿	36	11.0
子痫	11	3.4
血小板减少	7	2.1
肾功能衰竭	6	1.8
脑水肿	4	1.2
视网膜脱落	3	0.9
呼吸衰竭	2	0.6
产妇死亡	1	0.3

分组	例数	年龄(岁，±s)	孕次(次，±s)	产次(次，±s)	终止妊娠孕周(周，±s)	规律产检		大专及以上学历		入住ICU比率
分组	例数	年龄(岁，±s)	孕次(次，±s)	产次(次，±s)	终止妊娠孕周(周，±s)	例数	百分率(%)	例数	百分率(%)	例数	百分率(%)
研究组	327	30.2±5.9	2.6±1.5	0.7±0.8	30.9±4.3	55	16.8	51	15.6	88	26.9
对照组	478	30.3±5.4	2.3±1.4	0.5±0.6	34.2±3.3	123	25.7	156	32.6	19	6.1
统计值	?	t＝－0.311	t＝2.098	t＝3.766	t＝－12.442	χ²＝8.956		χ²＝29.514		χ²＝88.631
P值	?	0.756	0.036	0.000	0.000	0.003		0.000		0.000

分组	例数	年龄(岁，±s)	孕次(次，±s)	产次(次，±s)	终止妊娠孕周(周，±s)	规律产检		大专及以上学历		入住ICU比率
分组	例数	年龄(岁，±s)	孕次(次，±s)	产次(次，±s)	终止妊娠孕周(周，±s)	例数	百分率(%)	例数	百分率(%)	例数	百分率(%)
研究组	327	30.2±5.9	2.6±1.5	0.7±0.8	30.9±4.3	55	16.8	51	15.6	88	26.9
对照组	478	30.3±5.4	2.3±1.4	0.5±0.6	34.2±3.3	123	25.7	156	32.6	19	6.1
统计值	?	t＝－0.311	t＝2.098	t＝3.766	t＝－12.442	χ²＝8.956		χ²＝29.514		χ²＝88.631
P值	?	0.756	0.036	0.000	0.000	0.003		0.000		0.000

分组	例数	发病孕周(周)	期待时间(d)	收缩压(mmHg)	舒张压(mmHg)	24 h尿蛋白(g/L)	肌酐(μmol/L)	ALT(U/L)	白蛋白(g/L)
研究组	327	30.2±4.6	7.0±6.6	160.7±22.3	102.3±16.2	3.366±2.962	85.66±84.28	62.2±121.5	27.2±5.1
对照组	478	33.1±3.7	8.6±8.5	156.5±21.5	99.9±15.1	3.301±3.007	65.85±46.88	31.1±186.9	28.7±5.0
t值	?	－9.936	－2.912	2.630	2.207	0.281	4.241	2.640	－3.710
P值	?	0.000	0.004	0.009	0.028	0.779	0.000	0.008	0.000

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