To investigate the issues in blocking the mother-to-infant transmission of hepatitis B virus.

A total of 13, 672 HBV positive mothers and their 13, 982 newborns were enrolled in this cohort study in Foshan during 2017. We collected maternal and children′s information from the medical case management system. And we analyzed the influencing factors in blocking the mother-to-infant transmission of HBV.

The HBsAg positive rate of parturient was 10.14% in Foshan during 2017, the HBeAg positive rate was 24.13%, and the HBV DNA positive rate was about 5%. A total of 63 cases accepted antiviral treatment. The immunization globulin coverage rate was 99.84%. The rate of accepting 3 doses vaccination of HBV within one year after birth was 81.71%, and the rate of standardized vaccination was 62.65% (accepted vaccination at birth, one month and six month). The follow-up rate of all the fetus accepting HBV vaccine was 40.16%, and 34 (0.61%) fetus failed during the HBV blocking. The cause of blocking failure might included young age, HBeAg positive mothers and unregulated HBV vaccination. The main reason of clearly untested included refusal to examine the antibody, forgetting to examine the antibody, examine the antibody in advance, and couldn't provide test results accounted for 99.07%.

In order to realize zero transmission of HBV from mother to child in our city, we suggest to strengthen information communication and health education, implement HBV DNA detection and antiviral treatment for HBV positive pregnant women, increase the rate of standardized vaccination, and integrate this Hepatitis B two-and-a-half detection work of exposed children into the management of child health care.