To study the manifestations of pregnant patients with novel coronavirus omicron variant infection according to the background of Omicron variant strains currently prevalent in China.

The clinical data of 249 pregnant patients with novel coronavirus infection (COVID-19) in the Third Affiliated Hospital of Guangzhou Medical University from December 2022 to January 2023 were collected through questionnaire survey and analyzed retrospectively to summarize their clinical characteristics.

The age of 249 patients ranges from 22 to 45 years old, the onset of 249 patients in our hospital was concentrated in mid-December, which coincided with the peak period of the domestic epidemic period. 23(9.24%), 93(37.35%), and 129(51.81%) cases were onset in the early, middle and late pregnancy, respectively. The data for gestational weeks was absent in 4 cases. Among the 249 cases, there were 10 asymptomatic patients, 234(93.98%) mild or moderate patients, 4(1.61%) severe patients, and 1(0.40%) critical patient. The most common clinical symptoms were fever (74.5%), nasal congestion (68.2%), cough (68.2%), sore throat (52.3%) and general muscle aches (49.8%). The peak fevers in the first, middle and late stages of pregnancy were (38.60±0.87) ℃, (38.43±0.57) ℃ and (38.39±0.59) ℃, respectively, with no statistical difference. The duration of fever in the first trimester (2.17±0.96) days was significantly different from that in the second trimester (1.61±0.10) days (P=0.034), but not from that in the third trimester (1.73±0.10) days. 73.90% of the patient′s symptoms could be relieved by themselves, and 2.01% of the patients required intensive care.

Most of the pregnant patients with Omicron variants are mild to moderate, and severe and critical are rare. Clinically, symptoms such as fever, cough, nasal congestion, sore throat, and muscle aches are the most common symptoms. The average duration of fever in the first trimester is often longer than that in the second and third trimesters.