Efficacy of ergonovine in preventing hemorrhage of cesarean section in high-risk pregnant women

doi:10.3877/cma.j.issn.2095-3259.2018.03.014

Chinese Journal of Obstetric Emergency(Electronic Edition) ›› 2018, Vol. 07 ›› Issue (03): 180-184. doi: 10.3877/cma.j.issn.2095-3259.2018.03.014

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Efficacy of ergonovine in preventing hemorrhage of cesarean section in high-risk pregnant women

Liuying Zhong¹, Dunjin Chen¹^,^†(), Yanjie Ji², Gang Wang³, Hongying Hou⁴, Baoming Yin⁵, Bingmei Dai⁶, Weishe Zhang⁷, Dongmei He⁸, Ling Gao⁹, Guifeng Ding¹⁰, Qiying Zhu¹¹, Jin He¹², Chunxia Yin¹³, Yin Xu¹⁴, Wanli Gao¹⁵, Jinying Yang¹⁶

^1. Department of Obstetrics, Third Affiliated Hospital of Guangzhou Medical University, 510150 Guangzhou, China
^2. Department of Obstetrics and Gynecology, Dongguan Tangxia Hospital, 523721 Guangdong, China
^3. Department of Obstetrics and Gynecology, Foshan First People′s Hospital, 528000 Guandong, China
^4. Department of Obstetrics, iBorn Women′s & Chidren′s Hospital, 510635 Guangzhou, China
^5. Department of Obstetrics and Gynecology, Zhuhai Maternal and Child Health Hospital, 519001 Guangdong, China
^6. Department of Obstetrics and Gynecology, Dongguan Maternal and Child Health Hospital, 523112 Guangdong, China
^7. Department of Obstetrics, Central South University Xiangya Hospital, 410008 Changsha, China
^8. Department of Obstetrics and Gynecology, BING TUAN DI SI SHI YI YUAN, 835000 Yining, China
^9. Department of Obstetrics and Gynecology, First Agricultural Division Of Xinjiang Production And Construction Corps, 843000 Aksu, China
^10. Department of Obstetrics and Gynecology, Maternal and Child Health Care Hospital of Xinjiang Uygur Autonomous Region 830001 Urumqi, China
^11. Department of Obstetrics, First Affiliated Hospital of Xinjiang Medical University, 830054 Urumqi, China
^12. Department of Obstetrics and Gynecology, Jilin University Bethune First Hospital, 130021 Changchun, China
^13. Department of Obstetrics and Gynecology, Changchun Obstetrics and Gynecology Hospital, 140052 Changchun, China
^14. Department of Obstetrics and Gynecology, Guizhou Provincial People′s Hospital, 550002 Guiyang, China
^15. Department of Obstetrics and Gynecology, Daxing District People′s Hospital, 102600 Beijing, China
^16. Department of Obstetrics and Gynecology, Harbin Nangang District Obstetrics and Gynecology Hospital, 150080 Harbin, China

Received:2018-01-28 Online:2018-08-18 Published:2018-08-18
Contact: Dunjin Chen
About author:
Corresponding author: Chen Dunjin, Email: gzdrchen@gzhmu.edu.cn

Abstract

Abstract:

Objective

To evaluate the curative effect and safety of ergonovine in preventing bleeding during and after cesarean section in high risk pregnant women.

Methods

One thousand and seventy-four parturients with high risk factors of bleeding who underwent cesarean section in 16 hospitals of China were collected from February to June 2017. Patients were divided into three groups according to the use of different uterine contraction agents: group I (384 cases, oxytocin plus ergonovine were injected intraoperatively, oxytocin was injected after operation), group II (340 cases, oxytocin plus ergonovine were injected intraoperatively, ergonovine was injected after operation), control group (350 cases, oxytocin was injected intraoperatively and after operation). The bleeding volume and side effects of the operation, 2 h and 24 h after operation were analyzed and compared. Analysis of variance or Chi-square test was used for statistical analysis.

Results

In group II, the amount of blood loss of the operation, 2 h and 24 h after operation were (400.09±203.82) ml, (31.76±27.83)ml, (60.74±55.27)ml, respectively, which were significantly less than those in group I (451.33±441.43) ml, (66.30±43.08)ml, (83.62±56.89)ml, (P<0.05). The incidence rate of the patients used uterine contraction agent in group II was 5.29% (18 cases), which was smaller than those in group I (23.18%, 89 cases) and in the control group (29.14%, 102 cases), q=3.90 and 4.32, respectively, and P less than 0.05.

Conclusion

Ergonovine was effective and safe for high risk pregnant women with cesarean section to prevent intraoperative hemorrhage and postoperative hemorrhage, but close attention should be paid to the adverse drug reaction.

Key words: Ergonovine, Cesarean section, Pregnancy, high-risk

Liuying Zhong, Dunjin Chen, Yanjie Ji, Gang Wang, Hongying Hou, Baoming Yin, Bingmei Dai, Weishe Zhang, Dongmei He, Ling Gao, Guifeng Ding, Qiying Zhu, Jin He, Chunxia Yin, Yin Xu, Wanli Gao, Jinying Yang. Efficacy of ergonovine in preventing hemorrhage of cesarean section in high-risk pregnant women[J]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2018, 07(03): 180-184.

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References 16

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组别	例数	瘢痕子宫[例(%)]	多胎妊娠[例(%)]	巨大儿[例(%)]	前置胎盘[例(%)]	羊水过多[例(%)]	其他^*[例(%)]
研究组Ⅰ	384	173(45.05)	52(13.54)	100(26.04)	27(7.03)	12(3.13)	20(5.21)
研究组Ⅱ	340	156(45.88)	48(14.12)	91(26.76)	20(5.88)	10(2.94)	15(4.41)
对照组	350	168(48.00)	45(12.86)	92(26.29)	20(5.71)	9(2.57)	16(4.57)
χ²值	?	2.65	2.63	2.65	1.19	1.07	0.08
P值	?	0.157	0.159	0.157	0.335	0.399	0.789

组别	例数	瘢痕子宫[例(%)]	多胎妊娠[例(%)]	巨大儿[例(%)]	前置胎盘[例(%)]	羊水过多[例(%)]	其他^*[例(%)]
研究组Ⅰ	384	173(45.05)	52(13.54)	100(26.04)	27(7.03)	12(3.13)	20(5.21)
研究组Ⅱ	340	156(45.88)	48(14.12)	91(26.76)	20(5.88)	10(2.94)	15(4.41)
对照组	350	168(48.00)	45(12.86)	92(26.29)	20(5.71)	9(2.57)	16(4.57)
χ²值	?	2.65	2.63	2.65	1.19	1.07	0.08
P值	?	0.157	0.159	0.157	0.335	0.399	0.789

组别	例数	术中出血	术后2 h出血增量	术后24 h出血增量
研究组Ⅰ	384	300(200，500)	70(40，335)^a	200(75，474)^d
研究组Ⅱ	340	300(225，550)	50(20，273.75)^bc	170(50，193.75)^ef
对照组	350	300(210，410)	150(50，400)	375(260，550)
F值	?	3.827	13.109	14.763
P值	?	0.148	0.001	0.010

组别	例数	术中出血	术后2 h出血增量	术后24 h出血增量
研究组Ⅰ	384	300(200，500)	70(40，335)^a	200(75，474)^d
研究组Ⅱ	340	300(225，550)	50(20，273.75)^bc	170(50，193.75)^ef
对照组	350	300(210，410)	150(50，400)	375(260，550)
F值	?	3.827	13.109	14.763
P值	?	0.148	0.001	0.010

组别	例数	产后出血	输血	子宫缝合	宫腔填塞	使用治疗性宫缩剂
研究组Ⅰ	384	30(7.81)	4(1.04)	20(5.20)	6(1.56)	89(23.18)^a
研究组Ⅱ	340	13(3.82)	2(0.59)	5(1.47)	2(0.59)	18(5.29)^bc
对照组	350	41(11.71)	6(1.71)	14(4.00)	10(2.86)	102(29.14)
χ²值	?	－	－	－	－	67.00
P值	?	－	－	－	－	<0.01

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组别	例数	恶心	头痛	心率加快	心率变缓	高血压
研究组Ⅰ	23	10	7	2	5	1
研究组Ⅱ	21	9	3	4	6	2
对照组	13	4	5	2	2	0

组别	例数	恶心	头痛	心率加快	心率变缓	高血压
研究组Ⅰ	23	10	7	2	5	1
研究组Ⅱ	21	9	3	4	6	2
对照组	13	4	5	2	2	0

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