Early pregnancy complicated with hyperparathyroidism: a case report and review of the literature

doi:10.3877/cma.j.issn.2095-3259.2021.04.009

Abstract

Abstract:

Objective

To explore the clinical features, treatment options, timing and maternal and infant outcomes of pregnancy complicated with hyperparathyroidism.

Methods

We analyzed the clinical manifestation, diagnosis, treatment and outcome in 1 case of early pregnancy complicated with hyperparathyroidism, which were admitted in Xiaolan Hospital Affiliated of Southern Medical University, and 47 literature reported in the past 5 years.

Results

A 33-year old woman was admitted to the hospital due to hyperemesis gravidarum at 6 weeks of gestation. After treatment, the patient failed to improve and blood calcium was elevated. Pregnancy complicated with hyperparathyroidism was diagnosed. The patient requested termination of pregnancy and further surgical treatment. The patients were followed up for six months with good recovery of blood calcium and parathyroid hormone. Among the 47 pregnancies with primary hyperparathyroidism, 4 cases and 21 cases underwent parathyroidectomy in early and middle trimesters, respectively. The overall maternal and fetal outcomes were good, and there was no significant difference in preoperative blood calcium level.

Conclusions

Pregnancy complicated with hyperparathyroidism seriously endangers maternal and fetal safety, with high risk of misdiagnosis. Combined with clinical practice, patients can choose drug therapy in early pregnancy to reduce blood calcium level, and choose surgical treatment after middle pregnancy, which can effectively reduce the incidence of maternal and fetal complications.

Key words: Pregnancy trimester, first, Hyperparathyroidism, Drug therapy

Jianghong Zhao, Dongqin Yan, Meiting Huang, Yanping Yu. Early pregnancy complicated with hyperparathyroidism: a case report and review of the literature[J]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2021, 10(04): 230-235.

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手术时期	例数	剖宫产	孕母并发症		新生儿并发症
手术时期	例数	剖宫产	胰腺炎	肾结石	早产	死胎
早孕期	4	1	1	0	2	-
中孕期	22	10	3	7	4	-
晚孕期	5	3	2	1	3	-
产后	8	7	2(1例死亡)	3	3	-
拒绝手术	8	3	0	1	1例死胎	1

手术时期	例数	剖宫产	孕母并发症		新生儿并发症
手术时期	例数	剖宫产	胰腺炎	肾结石	早产	死胎
早孕期	4	1	1	0	2	-
中孕期	22	10	3	7	4	-
晚孕期	5	3	2	1	3	-
产后	8	7	2(1例死亡)	3	3	-
拒绝手术	8	3	0	1	1例死胎	1

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