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中华产科急救电子杂志 ›› 2012, Vol. 01 ›› Issue (02) : 131 -134. doi: 10.3877/cma.j.issn.2095-3259.2012.02.014

所属专题: 文献

论著

Syncytin-2 mRNA及其受体MFSD2 mRNA在正常妊娠及子痫前期胎盘组织中的表达研究
刘益芬1, 刘启才2, 陈敦金1,(), 赵扬3, 李映桃1, 李南1   
  1. 1. 510150 广州,广州医学院第三附属医院妇产科
    2. 广州医学院中心实验室
    3. 广东省人民医院妇产科
  • 收稿日期:2012-09-24 出版日期:2012-11-18
  • 通信作者: 陈敦金
  • 基金资助:
    广州市卫生局科研基金项目(201102A213179); 广州医学院科研基金(广医科[2010]1号); 广州医学院第三附属医院科研基金(2010Y07)

Expression of syncytin-2 mRNA and its receptor MFSD2 mRNA in human placenta in normal pregnancy and preeclampsia pregnancy

Yi-fen LIU1, Qi-cai LIU2, Dun-jin CHEN1,(), Yang ZHAO3, Ying-tao LI1, Nan LI1   

  1. 1. Department of Obstetrics and Gynaecology, the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China
  • Received:2012-09-24 Published:2012-11-18
  • Corresponding author: Dun-jin CHEN
  • About author:
    Corresponding author: CHEN Dun-jin, Email:
引用本文:

刘益芬, 刘启才, 陈敦金, 赵扬, 李映桃, 李南. Syncytin-2 mRNA及其受体MFSD2 mRNA在正常妊娠及子痫前期胎盘组织中的表达研究[J/OL]. 中华产科急救电子杂志, 2012, 01(02): 131-134.

Yi-fen LIU, Qi-cai LIU, Dun-jin CHEN, Yang ZHAO, Ying-tao LI, Nan LI. Expression of syncytin-2 mRNA and its receptor MFSD2 mRNA in human placenta in normal pregnancy and preeclampsia pregnancy[J/OL]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2012, 01(02): 131-134.

目的

检测syncytin-2 mRNA及其受体MFSD2 mRNA在正常妊娠及子痫前期胎盘组织中的表达及其与子痫前期发病的关系。

方法

分析2010年3月至2011年12月就诊于广州医学院第三附属医院住院分娩46例孕妇资料,正常妊娠组(21例),子痫前期组(25例)。在剖宫产术中采集产妇胎盘组织,采用实时荧光定量PCR法检测胎盘组织中syncytin-2 mRNA及其受体MFSD2 mRNA的表达,两组表达水平的比较采用t检验。

结果

Syncytin-2 mRNA及其受体MFSD2 mRNA在正常妊娠组及子痫前期组患者胎盘组织中均有表达。在子痫前期组,两种指标分别为5.59±0.29和0.79±0.08;在正常妊娠组,两种指标分别为6.99±0.62和0.83±0.10。两组中,syncytin-2 mRNA表达水平差异有统计学意义(t=2.331,P=0.029),MFSD2 mRNA表达水平差异无统计学意义(t=0.258,P=0.778)。

结论

胎盘组织syncytin2 mRNA表达下调可能与子痫前期发病密切相关,其受体MFSD2 mRNA与子痫前期发生无相关性。

Objective

To invest the expression of syncytin-2 mRNA and its receptor MFSD2 mRNA in human placenta of normal pregnant women and preeclampsia(PE) patients, and to studies the relationship between preeclampsia and the expression of syncytin-2 mRNA and MFSD2 mRNA.

Methods

Data of 46 pregnant women undergoing caesarean section in the Third Affiliated Hospital of Guangzhou Medical University from March 2010 to December 2011 were analyzed. Patients were divided into two grounds: 21 cases of normal pregnant women (normal group) and 25 cases of PE patients (PE ground). Syncytin-2 mRNA and MFSD2 mRNA in placenta were examined by real-time fluorescent quantitative PCR.The data were analyzed by using t-test.

Results

The expression of syncytin-2 mRNA and MFSD2 mRNA were detected in all cases. The expression of syncytin-2 mRNA and MFSD2 mRNA were 5.59±0.29 and 0.79±0.08 in the preeclampsia cases, while 6.99±0.62 and 0.83±0.10 in the normal group. Syncytin-2 mRNA were significantly lower in preeclampsia group than in normal group (t=2.331, P=0.029), but MFSD2 mRNA showed no significant difference in the two groups(t=0.258, P=0.778).

Conclusion

Down-regulated expression of syncytin-2 mRNA in human placenta may closely relate to the occurrence of PE, but there was no relationship between preeclampsia and receptor MFSD2 mRNA.

表1 PE组与正常妊娠组患者基本情况比较
表2 PE组与正常妊娠组患者胎盘syncytin-2 mRNA和MFSD2 mRNA水平测定结果
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