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中华产科急救电子杂志 ›› 2014, Vol. 03 ›› Issue (03) : 193 -195. doi: 10.3877/cma.j.issn.2095-3259.2014.03.011

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易栓症与不良妊娠结局的病理改变
贺芳1, 陈敦金1,()   
  1. 1. 510150 广州医科大学附属第三医院妇产科 广州重症孕产妇救治中心
  • 收稿日期:2014-06-10 出版日期:2014-08-18
  • 通信作者: 陈敦金

Pathological changes in thrombophilia with poor pregnancy outcomes

Fang He1, Dunjin Chen1()   

  • Received:2014-06-10 Published:2014-08-18
  • Corresponding author: Dunjin Chen
引用本文:

贺芳, 陈敦金. 易栓症与不良妊娠结局的病理改变[J/OL]. 中华产科急救电子杂志, 2014, 03(03): 193-195.

Fang He, Dunjin Chen. Pathological changes in thrombophilia with poor pregnancy outcomes[J/OL]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2014, 03(03): 193-195.

妊娠期血液处于高凝状态是生理性的血栓前状态,遗传性和获得性易栓症增加了孕妇血栓形成的几率。虽然易栓症与胎盘介导的妊娠期并发症相关,但是否为直接原因仍未证实。妊娠期易栓症不具备特征性的胎盘病变,故易栓症及妊娠不良结局与胎盘异常病理之间的关系值得进一步研究。

Pregnancy is a physiological prothrombotic state. Genetic and acquired thrombophilia increases the risk of maternal thrombophilia. Thrombophilia is not yet established as a cause of the placenta-mediated pregnancy complications, although the association between thrombophilia and placenta-mediated pregnancy complications is demonstrated. Maternal thrombophilia do not have a characteristic placental lesions. Future study on the relationship of abnormal placental pathology of poor pregnancy outcomes and thrombophilia should be considered.

表1 遗传性易栓症和复发性流产的风险评估[11]
[1]
Kujovich JL. Thrombophilia and pregnancy complications[J]. Am J Obstet Gynecol, 2004, 191(2): 412-424.
[2]
Rodger MA, Paidas M, McLintock C, et al. Inherited thrombophilia and pregnancy complications revisited[J]. Obstet Gynecol, 2008, 112(2 Pt 1): 320-324.
[3]
Rodger MA. An update on thrombophilia and placenta mediated pregnancy complications: what should we tell our patients?[J]. Thromb Res, 2013, 131 (Suppl 1): S25-S27.
[4]
Pierangeli SS, Leader B, Barilaro G, et al. Acquired and inherited thrombophilia disorders in pregnancy[J]. Obstet Gynecol Clin North Am, 2011, 38(2):271-295.
[5]
Heit JA, Kobbervig CE, James AH, et al. Trends in the incidence of venous thromboembolism during pregnancy or postpartum: a 30-year population-based study [J]. Ann Intern Med, 2005, 143(10): 697-706.
[6]
Brill-Edwards P, Ginsberg JS, Gent M, et al. Safety of withholding heparin in pregnant women with a history of venous thromboembolism. Recurrence of clot in this pregnancy study group[J]. N Engl J Med, 2000, 343(20): 1439-1444.
[7]
Gerhardt A, Scharf RE, Beckmann MW, et al. Prothrombin and factor V mutations in women with a history of thrombosis during pregnancy and the puerperium [J]. N Engl J Med, 2000, 342(6):374-380.
[8]
Tam WH, Ng MH, Yiu AK, et al. Thrombophilia among Chinese women with venous thromboembolism during pregnancy[J]. Gynecol Obstet Invest, 2012, 73(3):183-188.
[9]
Kupferminc MJ, Eldor A, Steinman N, et al. Increased frequency of genetic thrombophilia in women with complications of pregnancy[J]. N Engl J Med, 1999, 340(5):9-13.
[10]
Arias F, Romero R, Joist H, et al. Thrombophilia: a mechanism of disease in women with adverse pregnancy outcome and thrombotic lesions in the placenta [J]. J Matern Fetal Med, 1998, 7(6):277-286.
[11]
Robertson L, Wu O, Langhorne P, et al. Thrombophilia in pregnancy: a systematic review [J]. Br J Haematol, 2006, 132(2):171-196.
[12]
Moldenhauer JS, Stanek J, Warshak C, et al. The frequency and severity of placental findings in women with preeclampsia are gestational age dependent [J]. Am J Obstet Gynecol, 2003, 189(4):1173-1177.
[13]
Toal M, Keating S, Machin G, et al. Determinants of adverse perinatal outcome in high-risk women with abnormal uterine artery Doppler images[J]. Am J Obstet Gynecol, 2008, 198(3):330.e1-e7.
[14]
Giannakopoulos B, Krilis SA. The pathogenesis of the antiphospholipid syndrome[J]. N Engl J Med, 2013, 368(11):1033-1044.
[15]
Evain-Brion D, Guibourdenche J, Tsatsaris V, et al. Human trophoblast differentiation[J]. Bull Acad Natl Med, 2009, 193(5):1017-1025.
[16]
Franco C, Walker M, Robertson J, et al. Placental infarction and thrombophilia [J]. Obstet Gynecol, 2011, 117(4): 929-934.
[17]
Isermann B, Sood R, Pawlinski R, et al. The thrombomodulin-protein C system is essential for the maintenance of pregnancy [J]. Nat Med, 2003, 9(3): 331-337.
[18]
Battinelli EM, Marshall A, Connors JM. The role of thrombophilia in pregnancy[J]. Thrombosis, 2013, 2013: 516420.
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