切换至 "中华医学电子期刊资源库"

中华产科急救电子杂志 ›› 2018, Vol. 07 ›› Issue (04) : 208 -211. doi: 10.3877/cma.j.issn.2095-3259.2018.04.004

所属专题: 文献

专家论坛

早产预测的研究现状
玛丽帕提·马尔旦1, 时春艳1,()   
  1. 1. 100034 北京大学第一医院妇产科
  • 收稿日期:2018-08-30 出版日期:2018-11-18
  • 通信作者: 时春艳

Research status of premature birth prediction

maerdan Malipati•1, Chunyan Shi1()   

  • Received:2018-08-30 Published:2018-11-18
  • Corresponding author: Chunyan Shi
引用本文:

玛丽帕提·马尔旦, 时春艳. 早产预测的研究现状[J]. 中华产科急救电子杂志, 2018, 07(04): 208-211.

maerdan Malipati•, Chunyan Shi. Research status of premature birth prediction[J]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2018, 07(04): 208-211.

早产的预测手段包括病史、宫颈长度和阴道分泌物中生物标志物检测等。建议针对早产高危人群进行宫颈长度的筛查和监测。生物标记物对无症状孕妇的早产预测价值尚不能肯定,但对于先兆早产孕妇有一定的预测价值,可以联合宫颈长度的超声检测提高预测的准确性。今后仍然需要进一步研究预测方法的有效性。

Predictors of preterm birth include medical history, cervical length, and biomarkers of vaginal secretions. It is recommended to screen and monitor the cervical length for the pregnacies with high-risk preterm labor. The predictive value of biomarkers for preterm birth in asymptomatic pregnant women is not certain, but it has certain predictive value for pregnant women with threatened preterm birth. It can be combined with ultrasound detection of cervical length to improve the accuracy of prediction. Further research is needed to determine the effectiveness of the prediction method in the future.

[1]
Goldenberg RL, Culhane JF, Iams JD, et al. Epidemiology and causes of preterm birth [J]. Lancet, 2008, 371(9606): 75-84.
[2]
Romero R, Conde-Agudelo A, Da Fonseca E, et al. Vaginal progesterone for preventing preterm birth and adverse perinatal outcomes in singleton gestations with a short cervix: a meta-analysis of individual patient data [J]. Am J Obstet Gynecol, 2018, 218(2): 161-180.
[3]
Andersen HF, Nugent CE, Wanty SD, et a. Prediction of risk for preterm delivery by ultrasonographic measurement of cervical length [J]. Am J Obstet Gynecol, 1990, 163(3): 859-867.
[4]
Rozenberg P. Universal cervical length screening for singleton pregnancies with no history of preterm delivery, or the inverse of the Pareto principle [J]. BJOG, 2017, 124(7): 1038-1045.
[5]
Iams JD, Goldenberg RL, Meis PJ, et al. The length of the cervix and the risk of spontaneous premature delivery [J]. N Engl J Med, 1996, 334(9): 567-573.
[6]
时春艳,张云燕,金燕志,等. 阴道超声测量子宫颈长度及宫颈管宽度对预测早产的价值[J]. 中华妇产科杂志,2003, 38(5): 264-266.
[7]
曲首辉,时春艳,陈倩,等. 孕中、晚期孕妇子宫颈长度测量对早产的预测价值[J]. 中华妇产科杂志,2011, 46(10): 748-752.
[8]
Maerdan M, Shi C, Zhang X, et al. The prevalence of short cervix between 20 and 24 weeks of gestation and vaginal progesterone for prolongng of gestation [J]. J Matern Fetal Neonatal Med, 2017, 30(14): 1646-1649.
[9]
Kuusela P, Jacobsson B, Söderlund, M, et al. Transvaginal sonographic evaluation of cervical length in the second trimester of asymptomatic singleton pregnancies, and the risk of preterm delivery [J]. Acta obstetricia et gynecologica Scandinavica, 2015, 94(6): 598-607.
[10]
Fetal Medicine Foundation Cervical Assessment Certification [J/OL]. Available at: Accessed: February 8, 2016.

URL    
[11]
时春艳,杨慧霞,马京梅,等. 经阴道与经腹超声检测宫颈长度预测早产的价值[J]. 中国实用妇科与产科杂志,2009, 25(1): 40-42.
[12]
Newnham JP, White SW, Meharry S, et al. Reducing preterm birth by a statewide multifaceted program: an implementation study [J]. Ultrasound Obstet Gynecol, 2017, 216(5): 434-442.
[13]
Berghella V, Palacio M, Ness A, et al. Cervical length screening for prevention of preterm birth in singleton pregnancy with threatened preterm labor: systematic review and meta-analysis of randomized controlled trials using individual patient-level data [J]. Ultrasound Obstet Gynecol, 2017, 49(3): 322-329.
[14]
Berghella V, Saccone G. Fetal fibronectin testing for prevention of preterm birth in singleton pregnancies with threatened preterm labor: a systematic review and metaanalysis of randomized controlled trials [J]. Am J Obstet Gynecol, 2016, 215(4): 431-438.
[15]
Medley N, Poljak B, Mammarella S, et al. Clinical guidelines for prevention and management of preterm birth: a systematic review [J]. BJOG, 2018, 125(11): 1361-1369.
[16]
Temming LA, Durst JK, Tuuli MG, et al. Universal cervical length screening: implementation and outcomes [J]. Am J Obstet Gynecol, 2016, 214(4): 523.e1-523.e8.
[17]
Einerson BD, Grobman WA, Miller ES. Cost-effectiveness of risk-based screening for cervical length to prevent preterm birth [J]. Am J Obstet Gynecol., 2016, 215(1): 100.e1-100.e7.
[18]
Faron G, Balepa L, Parra J, et al. The fetal fibronectin test: 25 years after its development, what is the evidence regarding its clinical utility? A systematic review and meta-analysis [J]. J Matern Fetal Neonatal Med, 2018: 1-31.
[19]
Committee on Practice Bulletins—Obstetrics, The American College of Obstetricians and Gynecologists. ACOG practice bulletin no. 130: prediction and prevention of preterm birth [J]. Obstet Gynecol, 2012, 120(4): 964-973.
[20]
Esplin MS, Elovitz MA, Iams JD, et al. Predictive Accuracy of Serial Transvaginal Cervical Lengths and Quantitative Vaginal Fetal Fibronectin Levels for Spontaneous Preterm Birth Among Nulliparous Women [J]. JAMA, 2017, 317(10): 1047-1056.
[21]
Stock SJ, Wotherspoon LM, Boyd KA, et al. Quantitative fibronectin to help decision-making in women with symptoms of preterm labour (QUIDS) part 1: Individual participant data meta-analysis and health economic analysis [J]. BMJ open, 2018, 8(4): e020796.
[22]
Melchor JC, Khalil A, Wing D, et al. Prediction of preterm delivery in symptomatic women using placental alpha-microglobulin-1, fetal fibronectin and phosphorylated insulin-like growth factor-binding protein-1 tests: systematic review and meta-analysis stratified by risk [J]. Ultrasound Obstet Gynecol, 2018, 52(4): 442-451.
[23]
Eleje GU, Ezugwu EC, Eke AC, et al. Accuracy of a combined insulin-like growth factor-binding protein-1/interleukin-6 test (Premaquick) in predicting delivery in women with threatened preterm labor [J]. J Perinat Med, 2017, 45(8): 915-924.
[24]
Polettini J, Cobo T, Kacerovsky M, et al. Biomarkers of spontaneous preterm birth: a systematic review of studies using multiplex analysis [J]. J Perinat Med, 2017, 45(1): 71-84.
[25]
Holst RM, Hagberg H, Wennerholm UB, et al. Prediction of spontaneous preterm delivery in women with preterm labor: analysis of multiple proteins in amniotic and cervical fluids[J]. Obstet Gynecol, 2009, 114(2): 268-277.
[26]
Tsiartas P, Holst RM, Wennerholm UB, et al. Prediction of spontaneous preterm delivery in women with threatened preterm labour: a prospective cohort study of multiple proteins in maternal serum [J]. BJOG, 2012, 119(7): 866-873.
[1] 刘欢颜, 华扬, 贾凌云, 赵新宇, 刘蓓蓓. 颈内动脉闭塞病变管腔结构和血流动力学特征分析[J]. 中华医学超声杂志(电子版), 2023, 20(08): 809-815.
[2] 马艳波, 华扬, 刘桂梅, 孟秀峰, 崔立平. 中青年人颈动脉粥样硬化病变的相关危险因素分析[J]. 中华医学超声杂志(电子版), 2023, 20(08): 822-826.
[3] 陈旭渊, 罗仕云, 李文忠, 李毅. 腺源性肛瘘经手术治疗后创面愈合困难的危险因素分析[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 82-85.
[4] 唐旭, 韩冰, 刘威, 陈茹星. 结直肠癌根治术后隐匿性肝转移危险因素分析及预测模型构建[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 16-20.
[5] 吴方园, 孙霞, 林昌锋, 张震生. HBV相关肝硬化合并急性上消化道出血的危险因素分析[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 45-47.
[6] 晏晴艳, 雍晓梅, 罗洪, 杜敏. 成都地区老年转移性乳腺癌的预后及生存因素研究[J]. 中华普外科手术学杂志(电子版), 2023, 17(06): 636-638.
[7] 莫闲, 杨闯. 肝硬化患者并发门静脉血栓危险因素的Meta分析[J]. 中华普外科手术学杂志(电子版), 2023, 17(06): 678-683.
[8] 侯超, 潘美辰, 吴文明, 黄兴广, 李翔, 程凌雪, 朱玉轩, 李文波. 早期食管癌及上皮内瘤变内镜黏膜下剥离术后食管狭窄的危险因素[J]. 中华消化病与影像杂志(电子版), 2023, 13(06): 383-387.
[9] 陆猛桂, 黄斌, 李秋林, 何媛梅. 蜂蛰伤患者发生多器官功能障碍综合征的危险因素分析[J]. 中华临床医师杂志(电子版), 2023, 17(9): 1010-1015.
[10] 李达, 张大涯, 陈润祥, 张晓冬, 黄士美, 陈晨, 曾凡, 陈世锔, 白飞虎. 海南省东方市幽门螺杆菌感染现状的调查与相关危险因素分析[J]. 中华临床医师杂志(电子版), 2023, 17(08): 858-864.
[11] 李琪, 黄钟莹, 袁平, 关振鹏. 基于某三级医院的ICU多重耐药菌医院感染影响因素的分析[J]. 中华临床医师杂志(电子版), 2023, 17(07): 777-782.
[12] 王亚丹, 吴静, 黄博洋, 王苗苗, 郭春梅, 宿慧, 王沧海, 王静, 丁鹏鹏, 刘红. 白光内镜下结直肠肿瘤性质预测模型的构建与验证[J]. 中华临床医师杂志(电子版), 2023, 17(06): 655-661.
[13] 孟科, 李燕, 闫婧爽, 闫斌. 胶囊内镜胃通过时间的影响因素分析[J]. 中华临床医师杂志(电子版), 2023, 17(06): 671-675.
[14] 杨艳丽, 陈昱, 赵若辰, 杜伟, 马海娟, 许珂, 张莉芸. 系统性红斑狼疮合并血流感染的危险因素及细菌学分析[J]. 中华临床医师杂志(电子版), 2023, 17(06): 694-699.
[15] 孙培培, 张二明, 时延伟, 赵春燕, 宋萍萍, 张硕, 张克, 周玉娇, 赵璨, 闫维, 吴蓉菊, 宋丽萍, 郭伟安, 马石头, 安欣华, 包曹歆, 向平超. 北京市石景山区40岁及以上居民慢性阻塞性肺疾病患病情况及相关危险因素分析[J]. 中华临床医师杂志(电子版), 2023, 17(06): 711-719.
阅读次数
全文


摘要