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中华产科急救电子杂志 ›› 2018, Vol. 07 ›› Issue (04) : 212 -215. doi: 10.3877/cma.j.issn.2095-3259.2018.04.005

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感染相关早产的防治
刘平1, 樊尚荣1,()   
  1. 1. 518036 深圳,北京大学深圳医院妇产科
  • 收稿日期:2018-08-13 出版日期:2018-11-18
  • 通信作者: 樊尚荣
  • 基金资助:
    深圳市科创委基础研究项目(JCYJ20160428175005906)

Prevention and treatment of infection­related preterm birth

Ping Liu1, Shangrong Fan1()   

  • Received:2018-08-13 Published:2018-11-18
  • Corresponding author: Shangrong Fan
引用本文:

刘平, 樊尚荣. 感染相关早产的防治[J]. 中华产科急救电子杂志, 2018, 07(04): 212-215.

Ping Liu, Shangrong Fan. Prevention and treatment of infection­related preterm birth[J]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2018, 07(04): 212-215.

羊膜腔感染是感染相关早产的重要影响因素。羊膜腔感染后炎症引起子宫收缩或伴胎膜早破,导致早产;炎症同时引起胎儿缺氧和死胎。早产儿感染后可发生呼吸窘迫综合征、缺氧缺血性脑病和脑瘫。本文对感染相关早产的发病机制和防治策略进行阐述。

Intra-amniotic infection is an important influencing factor of infection-related preterm birth. Inflammation of intra-amniotic infection can cause uterine contraction or premature rupture of membranes, which leads to premature labor; inflammation also causes fetal hypoxia and stillbirth. In addition, respiratory distress syndrome, hypoxic ischemic encephalopathy and cerebral palsy occur in preterm infants after infection.

图1 感染相关早产的发病机制。羊膜腔感染分为4期:A.下生殖道感染;B.绒毛膜羊膜感染;C.羊水感染;D.胎儿感染。HIE:缺氧缺血性脑病;RDS:呼吸窘迫综合征
[1]
Purisch SE, Gyamfi-Bannerman C. Epidemiology of preterm birth [J]. Semin Perinatol, 2017, 41(7): 387-391.
[2]
Hamilton BE, Martin JA, Osterman MJ. Births: preliminary data for 2015[J]. Natl Vital Stat Rep, 2016, 65(3): 1-15.
[3]
Ferré C, Callaghan W, Olson C, et al. Effects of maternal age and age-specific preterm birth rates on overall preterm birth rates-united states, 2007 and 2014 [J]. Mmwr Morb Mortal Wkly Rep, 2016, 65(43): 1181-1184.
[4]
Rundell K, Panchal B. Preterm Labor: prevention and management [J]. Am Fam Physician, 2017, 95(6): 366-372.
[5]
Lei J, Xie L, Zhao H, et al. Maternal CD8+ T-cell depletion alleviates intrauterine inflammation-induced perinatal brain injury [J]. Am J Reprod Immunol, 2018, 79(5): e12798.
[6]
Paules C, Pueyo V, Martí E, et al. Threatened preterm labor is a risk factor for impaired cognitive development in early childhood [J]. Am J Obstet Gynecol, 2017, 216(2): 157.e1-157.e7.
[7]
Cappelletti M, Della Bella S, Ferrazzi E, et al. Inflammation and preterm birth [J]. J Leukoc Biol, 2016, 99(1): 67-78.
[8]
Boyle AK, Rinaldi SF, Norman JE, et al. Preterm birth: inflammation, fetal injury and treatment strategies [J]. J Reprod Immunol, 2016, 119: 62-66.
[9]
Ronald FL. Advances in the prevention of infection-related preterm birth [J]. Front Immunol, 2015, 6: 566.
[10]
Helmo FR, Alves EAR, Moreira RAA, et al. Intrauterine infection, immune system and premature birth[J]. J Matern Fetal Neonatal Med, 2018, 31(9): 1227-1233.
[11]
Martinez-varea A, Romero R, Xu Y, et al. Clinical chorioamnionitis at term VII: the amniotic fluid cellular immune response [J]. J Perinat Med, 2016, 45(5): 523-538.
[12]
Gomezlopez N, Romero R, Xu Y, et al. A role for the inflammasome in spontaneous labor at term with acute histologic chorioamnionitis [J]. Reprod Sci, 2017, 24(6): 934-953.
[13]
van Well GTJ, Daalderop LA, Wolfs T, et al. Human perinatal immunity in physiological conditions and during infection [J]. Mol Cell Pediatr, 2017, 4(1): 4.
[14]
时春艳,樊尚荣. 羊膜腔感染的诊断和处理[J/CD]. 中华产科急救电子杂志,2013, 2(2):111-115
[15]
Kyung Joon, Sun Min Kim. Twenty-four percent of patients with clinical chorioamnionitis in preterm gestations have no evidence of either culture-proven intra-amniotic infection or intra-amniotic inflammation[J]. Am J Obstet Gynecol, 2017, 216(6): 604.e1-604.e11.
[16]
Romero R, Chaemsaithong P, Korzeniewski SJ, et al. Clinical chorioamnionitis at term II: the intra-amniotic inflammatory response[J]. J Perinat Med, 2016, 44(1): 5-22.
[17]
Redline RW, Faye-petersen O, Heller D, et al. Amniotic infection syndrome: nosology and reproducibility of placental reaction patterns[J]. Pediatr Dev Pathol, 2003, 6(5): 435-448.
[18]
Goedicke-Fritz S, Härtel C, Krasteva-Christ G, et al. Preterm birth affects the risk of developing immune-mediated diseases [J]. Front Immunol, 2017, 8: 1266.
[19]
Nadeau HC, Subramaniam A, Andrews WW. Infection and preterm birth [J]. Semin Fetal Neonatal Med, 2016, 21(2): 100-105.
[20]
Sentilhes L, Sénat MV, Ancel PY, et al. Prevention of spontaneous preterm birth: Guidelines for clinical practice from the French College of Gynaecologists and Obstetricians (CNGOF)[J]. Eur J Obstet Gynecol Reprod Biol, 2017, 210: 217-224.
[21]
Yudin MH, Money DM. No.211-Screening and management of bacterial vaginosis in pregnancy [J]. J Obstet Gynaecol Can, 2017, 39(8): e184-e191.
[22]
Hosny AEMS, El-Khayat W, Kashef MT, et al. Association between preterm labor and genitourinary tract infections caused by Trichomonas vaginalis, Mycoplasma hominis, Gram-negative bacilli, and coryneforms[J]. Chin Med Assoc, 2017, 80(9): 575-581.
[23]
Rantsi T, Joki-Korpela P, Wikström E, et al. Population-based study of prediagnostic antibodies to Chlamydia trachomatis in relation to adverse pregnancy outcome[J]. Sex Transm Dis, 2016, 43(6): 382-387.
[24]
Adachi K, Klausner JD, Xu J, et al. Chlamydia trachomatis and Neisseria gonorrhoeae in HIV-infected pregnant women and adverse infant outcomes[J]. Pediatr Infect Dis, 2016, 35(8): 894-900.
[25]
Reekie J, Robert C, Preen D, et al. Chlamydia trachomatis, and the risk of spontaneous preterm birth, babies who are born small for gestational age, and stillbirth: a population-based cohort study [J]. Lancet Infectious Diseases, 2018, 18(4): 452-460.
[26]
Teshome A, Yitayeh A. Relationship between periodontal disease and preterm low birth weight: systematic review [J]. Pan Afr Med J, 2016, 24: 215.
[27]
Lai YJ, Hsu TY, Lan KC, et al. Asymptomatic pyuria in pregnant women during the first trimester is associated with an increased risk of adverse obstetrical outcomes [J]. Taiwan J Obstet Gynecol, 2017, 56(2): 192-195.
[28]
时春艳,漆洪波,杨慧霞. 胎膜早破的诊断与处理指南(2015)[J]. 中华妇产科杂志,2015, 50(1): 161-167.
[29]
Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 188: prelabor rupture of membranes [J]. Obstet Gynecol, 2018, 131(1): e1-e12.
[30]
Higgins RD, Saade G, Polin RA, et al. Evaluation and management of women and newborns with a maternal diagnosis of chorioamnionitis: summary of a workshop[J]. Obstet Gynecol, 2016, 127(3): 426-436.
[31]
American College of Obstetricians and Gynecologists′ Committee on Practice Bulletins-Obstetrics. Practice Bulletin No.172: premature rupture of membranes[J]. Obstet Gynecol, 2016, 128(4): e165-177.
[32]
Randis TM, Polin RA, Saade G. Chorioamnionitis: time for a new approach[J]. Curr Opin Pediatr, 2017, 29(2): 159-164.
[33]
American College of Obstetricians and Gynecologists′ Committee on Practice Bulletins-Obstetrics. Practice Bulletin No.171: management of preterm labor[J]. Obstet Gynecol, 2016, 128(4): e155-164.
[34]
Tsakiridis I, Mamopoulos A, Chalkia-Prapa EM, et al. Preterm premature rupture of membranes: a review of 3 national guidelines[J]. Obstet Gynecol Surv, 2018, 73(6): 368-375.
[35]
Jain J, Gyamfi-Bannerman C. Future directions in preterm birth research [J]. Semin Fetal Neonatal Med, 2016, 21(2): 129-132.
[36]
Musilova I, Bestvina T, Hudeckova M, et al. Vaginal fluid IL-6 concentrations as a point-of-care test is of value in women with preterm PROM[J]. Am J Obstet Gynecol, 2016, 9(16): e11-e12.
[37]
Van der Krogt L, Ridout AE, Seed PT, et al. Placental inflammation and its relationship to cervicovaginal fetal fibronectin in preterm birth[J]. Eur J Obstet Gynecol Reprod Biol, 2017, 214: 173-177.
[38]
Cobo T, Kacerovsky M, Jacobsson B. Noninvasive sampling of the intrauterine environment in women with preterm labor and intact membranes[J]. Fetal Diagn Ther, 2018, 43(4): 241-249.
[39]
Wang KC, Lee WL, Wang PH. Lactobacillus supplementation and Group B streptococcus infection[J]. Taiwan J Obstet Gynecol, 2017, 56(1): 121-122.
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