At present, the amount of pregnancies with advanced age has increased dramatically. As maternal age increasing, the fertility, glucose and lipid metabolism decreased. The incidence rate of physical disease, surgical disease and gynecological disease is higher and higher. The above risk factors increase maternal and fetal adverse pregnancy outcomes, including gestational diabetes mellitus, hypertensive disorder complicating pregnancy, placenta previa, placenta increta, fetal malformation, miscarriage, preterm birth, macrosomia, intrauterine growth restriction and other pregnancy complications. In addition, the risks of the uterine rupture, postpartum hemorrhage, amniotic fluid embolism and postpartum thrombosis increase according to the rate of cesarean rising. Do well in antenatal assessment and management during pregnancy through analyzing various risk factors at women with advanced age, which is vital to ensure maternal and fetal safety.