Impact of pregnant women with advanced age on fetal disease

doi:10.3877/cma.j.issn.2095-3259.2016.03.011

Abstract

Abstract:

Objective

To explore the impact of pregnant women with advanced age on fetal disease.

Methods

A clinical data of 28 897 singleton pregnancies who delivered from January 2009 to December 2014 in The Third Affiliated Hospital of Guangzhou Medical University were retrospectively analyzed. According to the maternal age, all cases were divided into ≥35 years group (n=3 670), and 18-34 years group (n=25 227). The fetal disease rates of two the groups were analyzed by Chi-square test and U test.

Results

The percentage of singleton pregnancies at the age of 35 years and older was 12.70%, and the percentage of patients between 18 and 34 was 87.30%. The rate of total fetal diseases in ≥35 years group was higher than that in 18-34 years group (2.62% and 2.04%, χ²=5.106, P=0.024). And the rates of fetal death, fetal chromosome abnormality and fetal multiple malformations in ≥35 years group (1.66%, 0.57% and 1.36‰, respectively) were higher than those in 18-34 years group (1.41%, 0.12% and 0.44‰), P values less than 0.05.

Conclusion

The rates of fetal death, fetal chromosome abnormality and fetal multiple malformations increase in pregnancies with advanced age.

Key words: Maternal age, Fetal diseases, Fetal death, Chromosome aberrations, Congenital abnormalities

Chunyan Wang, Jingjin Gong, Sihui Li, Xiaoyan Wang, Dunjin Chen. Impact of pregnant women with advanced age on fetal disease[J]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2016, 05(03): 173-177.

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References 24

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组别	例数	孕次(次，±s)	产次(次，±s)	体重指数(kg/m²，±s)	辅助生殖技术授孕
组别	例数	孕次(次，±s)	产次(次，±s)	体重指数(kg/m²，±s)	例数	千分率(‰)
≥35岁组	3 670	2.78±1.55	0.62±0.72	23.80±3.27	73	19.89
18～34岁组	25 227	1.84±1.10	0.26±0.52	22.16±3.09	365	14.47
统计值	?	U＝2.854	U＝3.298	U＝1.174	χ²＝6.311
P值	?	0.000	0.000	0.000	0.012

组别	例数	孕次(次，±s)	产次(次，±s)	体重指数(kg/m²，±s)	辅助生殖技术授孕
组别	例数	孕次(次，±s)	产次(次，±s)	体重指数(kg/m²，±s)	例数	千分率(‰)
≥35岁组	3 670	2.78±1.55	0.62±0.72	23.80±3.27	73	19.89
18～34岁组	25 227	1.84±1.10	0.26±0.52	22.16±3.09	365	14.47
统计值	?	U＝2.854	U＝3.298	U＝1.174	χ²＝6.311
P值	?	0.000	0.000	0.000	0.012

组别	例数	染色体异常		21-三体综合征		18-三体综合征		多发畸形
组别	例数	例数	千分率(‰)	例数	千分率(‰)	例数	千分率(‰)	例数	千分率(‰)
≥35岁组	3 670	21	5.72	13	3.54	4	1.09	5	1.36
18～34岁组	25 227	30	1.19	15	0.59	6	0.24	11	0.44
χ²值	?	37.368		28.757		6.730		4.968
P值	?	0.000		0.000		0.009		0.026

组别	例数	染色体异常		21-三体综合征		18-三体综合征		多发畸形
组别	例数	例数	千分率(‰)	例数	千分率(‰)	例数	千分率(‰)	例数	千分率(‰)
≥35岁组	3 670	21	5.72	13	3.54	4	1.09	5	1.36
18～34岁组	25 227	30	1.19	15	0.59	6	0.24	11	0.44
χ²值	?	37.368		28.757		6.730		4.968
P值	?	0.000		0.000		0.009		0.026

组别	例数	先天性心脏病		Duang-Walker综合征		单脐动脉		唇腭裂
组别	例数	例数	千分率(‰)	例数	千分率(‰)	例数	千分率(‰)	例数	千分率(‰)
≥35岁组	3 670	17	4.63	2	0.54	10	2.72	7	1.91
18～34岁组	25 227	117	4.64	12	0.48	35	1.39	40	1.59
χ²值	?	0.000		0.032		3.686		0.204
P值	?	0.996		0.859		0.055		0.651
组别	例数	多囊肾		四肢畸形		消化系统畸形		中枢神经系统畸形
组别	例数	例数	千分率(‰)	例数	千分率(‰)	例数	千分率(‰)	例数	千分率(‰)
≥35岁组	3 670	2	0.54	2	0.54	5	1.36	4	1.09
18～34岁组	25 227	14	0.55	6	0.24	18	0.71	21	0.83
χ²值	?	0.001		1.092		1.696		0.246
P值	?	0.981		0.296		0.139		0.620

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