Analysis of causes of intrauterine fetal death in pregnant women with advanced age

doi:10.3877/cma.j.issn.2095-3259.2016.03.012

Abstract

Abstract:

Objective

To explore the causes of intrauterine fetal death in pregnancy women with advanced age.

Methods

Clinical data of 339 intrauterine fetal deaths (single fetus) were retrospectively analyzed. The patients were admitted to the obstetrics and gynecology department at The Third Affiliated Hospital of Guangzhou Medical University from January 1, 2009 to December 31, 2014. According to the age of pregnant woman at deliver, the cases were divided into advanced age group (≥35 years) or and non-advanced age group (20-34 years). The causes of intrauterine fetal deaths were compared between the two groups. Independent sample t test, Chi-square test or Fisher′s exact test were used for statistical analysis.

Results

The incidence of intrauterine fetal death was higher in advanced age group when compared with non-advanced age group [1.66% (61/3 670) vs. 1.10% (278/25 227), χ²=8.670, P=0.003]. There were no significant differences of maternal complications incidences between the two groups (all P vales more than 0.05). The rates of unknown factors of intrauterine fetal death in advanced age group and non-advanced age group were [27.87% (17/61) and 7.55% (21/278) respectively, χ²=20.74, P=0.000].

Conclusion

Pregnancy women with advanced age present a higher risk of intrauterine fetal death than the non-advanced ones, so strengthen the maternal-fetal monitoring of pregnancy women with advanced age.

Key words: Maternal age, Fetal death, Risk factors

Jingjin Gong, Xiaomei Li, Sihui Li, Xiuying Li, Dunjin Chen. Analysis of causes of intrauterine fetal death in pregnant women with advanced age[J]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2016, 05(03): 178-181.

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Figures/Tables 3

References 15

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组别	例数	既往孕次	规律产检		大学及以上学历		分娩孕周	死胎发生孕周
		(次，±s)	例数	百分率(%)	例数	百分率(%)	(周，±s)	≥37周		28～36周		20～27^＋6周
		(次，±s)	例数	百分率(%)	例数	百分率(%)	(周，±s)	例数	百分率(%)	例数	百分率(%)	例数	百分率(%)
高龄组	3 670	3.08±1.58	10	16.39	14	22.95	29.21±6.13	10	16.39	21	34.43	30	49.18
非高龄组	25 227	2.20±1.26	34	12.23	34	12.23	29.17±5.51	28	10.07	129	46.40	121	43.53
统计值	?	t＝4.067	χ²＝0.768		χ²＝0.350		t＝0.962	χ²＝2.008		χ²＝2.909		χ²＝0.648
P值	?	0.036	0.381		0.554		0.962	0.156		0.088		0.421

组别	例数	既往孕次	规律产检		大学及以上学历		分娩孕周	死胎发生孕周
		(次，±s)	例数	百分率(%)	例数	百分率(%)	(周，±s)	≥37周		28～36周		20～27^＋6周
		(次，±s)	例数	百分率(%)	例数	百分率(%)	(周，±s)	例数	百分率(%)	例数	百分率(%)	例数	百分率(%)
高龄组	3 670	3.08±1.58	10	16.39	14	22.95	29.21±6.13	10	16.39	21	34.43	30	49.18
非高龄组	25 227	2.20±1.26	34	12.23	34	12.23	29.17±5.51	28	10.07	129	46.40	121	43.53
统计值	?	t＝4.067	χ²＝0.768		χ²＝0.350		t＝0.962	χ²＝2.008		χ²＝2.909		χ²＝0.648
P值	?	0.036	0.381		0.554		0.962	0.156		0.088		0.421

组别	例数	妊娠期高血压疾病		妊娠期糖尿病		系统性红斑狼疮		急性左心衰		羊水量异常		前置胎盘
组别	例数	例数	百分率(%)	例数	百分率(%)	例数	百分率(%)	例数	百分率(%)	例数	百分率(%)	例数	百分率(%)
高龄组	61	30	49.18	8	13.11	1	1.64	3	4.92	7	6.56	2	3.28
非高龄组	278	108	38.85	18	6.47	10	3.60	4	1.44	20	4.68	27	9.71
χ²值	?	2.212		3.114		0.611		2.994		1.251		2.647
P值	?	0.137		0.078		0.696		0.113		0.294		0.104
组别	例数	胎盘早剥		绒毛膜羊膜炎		脐带绕颈		脐带扭转		胎儿严重畸形		胎儿生长受限
组别	例数	例数	百分率(%)	例数	百分率(%)	例数	百分率(%)	例数	百分率(%)	例数	百分率(%)	例数	百分率(%)
高龄组	61	7	11.48	4	6.56	5	8.20	5	8.20	5	8.20	4	6.56
非高龄组	278	24	8.63	10	3.60	17	6.12	27	9.71	36	12.95	14	5.04
χ²值	?	0.486		1.107		0.357		0.134		1.063		0.230
P值	?	0.486		0.290		0.566		0.714		0.303		0.544

组别	例数	妊娠期高血压疾病		妊娠期糖尿病		系统性红斑狼疮		急性左心衰		羊水量异常		前置胎盘
组别	例数	例数	百分率(%)	例数	百分率(%)	例数	百分率(%)	例数	百分率(%)	例数	百分率(%)	例数	百分率(%)
高龄组	61	30	49.18	8	13.11	1	1.64	3	4.92	7	6.56	2	3.28
非高龄组	278	108	38.85	18	6.47	10	3.60	4	1.44	20	4.68	27	9.71
χ²值	?	2.212		3.114		0.611		2.994		1.251		2.647
P值	?	0.137		0.078		0.696		0.113		0.294		0.104
组别	例数	胎盘早剥		绒毛膜羊膜炎		脐带绕颈		脐带扭转		胎儿严重畸形		胎儿生长受限
组别	例数	例数	百分率(%)	例数	百分率(%)	例数	百分率(%)	例数	百分率(%)	例数	百分率(%)	例数	百分率(%)
高龄组	61	7	11.48	4	6.56	5	8.20	5	8.20	5	8.20	4	6.56
非高龄组	278	24	8.63	10	3.60	17	6.12	27	9.71	36	12.95	14	5.04
χ²值	?	0.486		1.107		0.357		0.134		1.063		0.230
P值	?	0.486		0.290		0.566		0.714		0.303		0.544

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