Application of sodium citrate anticoagulant for hemoperfusion in hypertriglyceridemia-induced acute pancreatitis in pregnancy

doi:10.3877/cma.j.issn.2095-3259.2018.01.010

Abstract

Abstract:

Objective

To explore the curative effect of sodium citrate anticoagulant for hemoperfusion on hypertriglyceridemia-induced acute pancreatitis in pregnancy.

Methods

A retrospective study was conducted in 19 pregnant patients with hypertriglyceridemia-induced acute pancreatitis. The clinical manifestation and laboratory index of the patients before and after hemoperfusion with sodium citrate anticoagulant were compared.

Results

After hemoperfusion with sodium citrate anticoagulant, the ACPAHEⅡscores of patients reduced from(14.8±4.7) scores to (6.3±1.3) scores, t=5.167, triglyceride from(30.44±7.37) mmol/L to(4.5±1.2) mmol/L, t=5.167, amylase from (1028.76±293.27)U/L to (105.3±65.1)U/L, t=2.861, all P<0.01.

Conclusion

The hemoperfusion with sodium citrate anticoagulant can improve clinical symptom and prognosis of pregnant patients with hypertriglyceridemia-induced acute pancreatitis.

Key words: Poncirus, Perfusion, Blood, Pregnancy complications, Hyperlipidemias, Pancreatitis

Yuanmei Gao, Dongjian Huang, Guangyuan Liao, Jing Li, Zhaohui Gan, Zhong Xu, Dunjin Chen. Application of sodium citrate anticoagulant for hemoperfusion in hypertriglyceridemia-induced acute pancreatitis in pregnancy[J]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2018, 07(01): 48-51.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhckjjdzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-3259.2018.01.010

https://zhckjjdzzz.cma-cmc.com.cn/EN/Y2018/V07/I01/48

Figures/Tables 3

References 12

[1]	Amin T, Poon LC, Teoh TG, et al. Management of hypertriglyceridaemia-induced acute pancreatitis in pregnancy [J]. J Matern Fetal Neonatal Med, 2015, 28(8): 954-958.
[2]	甘婷，肖国宏，陈敦金. 妊娠合并急性胰腺炎的病因及诊疗 [J/CD]. 中华产科急救电子杂志，2012, 1(1)：61-64.
[3]	中华医学会外科学分会胰腺外科学组. 急性胰腺炎诊治指南(2014). 中国实用外科杂志，2015, 1(35): 4-7.
[4]	李茂琴，史载祥，许继元，等. 血液灌流联合连续性静脉-静脉血液透析滤过对高脂血症性重症急性胰腺炎的疗效分析 [J/CD]. 中华危重症医学杂志：电子版，2016, 9(1)：38-40.
[5]	迟心左. 妊娠合并高脂血症性重症急性胰腺炎 [J]. 中华临床医师杂志，2012, 6(1)：123-125.
[6]	府伟灵，徐克前. 临床生物化学检验 [M]. 5版. 人民卫生出版社，2012: 330.
[7]	Yadav D, Pitchumoni CS. Issues in hyperlipidemic panereatitis [J]. J Clin Gastreenterol, 2003, 36(1): 54-62.
[8]	Scherer J, Singh VP, Pitchumoni CS, et al. Issues in hypertriglyceridemic pancreatitis: an update [J]. J Clin Gastroenterol, 2014, 48(3): 195-203.
[9]	乔红，王东信. 妊娠期及产后合并急性胰腺炎的临床分析 [J]. 中国妇产科临床杂志，2017, 1(18)：50-52.
[10]	欧娅，苏伟，杨自力，等. 中性大孔径树脂治疗吸附柱的直接血液灌流早期治疗重症急性胰腺炎 [J]. 实用医学杂志，2014, 30(8)：1225-1227.
[11]	郑寅，丁峰. 局部枸橼酸抗凝在连续性肾脏替代治疗中的应用 [J]. 中国血液净化，2015, 14(1)：47-50.
[12]	杨静，白智远. 局部枸橼酸抗凝在连续性肾脏替代治疗中的应用研究进展 [J]．临床合理用药，2016, 9(2C)：176-178.

组别	例数	体温(℃)	心率(次/min)	呼吸(次/min)	平均动脉压(mmHg)	APCHEⅡ评分(分)
治疗前	19	37.2±1.2	105.1±28.5	21.7±1.5	81.9±7.3	14.8±4.7
治疗后	19	36.1±0.1	78.3±6.8	18.7±1.0	78.5±4.5	6.3±1.3
t值	?	4.651	4.930	3.160	2.446	5.167
P值	?	<0.001	<0.001	0.006	0.026	<0.001

组别	例数	体温(℃)	心率(次/min)	呼吸(次/min)	平均动脉压(mmHg)	APCHEⅡ评分(分)
治疗前	19	37.2±1.2	105.1±28.5	21.7±1.5	81.9±7.3	14.8±4.7
治疗后	19	36.1±0.1	78.3±6.8	18.7±1.0	78.5±4.5	6.3±1.3
t值	?	4.651	4.930	3.160	2.446	5.167
P值	?	<0.001	<0.001	0.006	0.026	<0.001

组别	例数	白细胞计数(×10⁹/L)	血淀粉酶(U/L)	甘油三脂(mmol/L)	胆固醇(mmol/L)
治疗前	19	14.1±4.3	1028.76±293.27	30.44±7.37	17.7±8.9
治疗后	19	8.2±2.3	105.3±65.1	4.5±1.2	7.8±2.4
t值	?	3.862	2.861	5.321	4.938
P值	?	0.001	0.011	<0.001	<0.001

组别	例数	白细胞计数(×10⁹/L)	血淀粉酶(U/L)	甘油三脂(mmol/L)	胆固醇(mmol/L)
治疗前	19	14.1±4.3	1028.76±293.27	30.44±7.37	17.7±8.9
治疗后	19	8.2±2.3	105.3±65.1	4.5±1.2	7.8±2.4
t值	?	3.862	2.861	5.321	4.938
P值	?	0.001	0.011	<0.001	<0.001

组别	例数	血小板计数(×10⁹/L)	APTT(s)	碳酸氢根(mmol/L)	血清iCa^2＋(mmol/L)	血清Na^＋(mmol/L)
治疗前	19	283.2±73.3	30.8±3.7	15.3±4.8	0.8±0.1	130.2±5.2
治疗后	19	286.2±75.3	29.5±2.7	20.2±1.3	1.1±0.1	136.7±2.8
t值	?	1.468	1.486	－6.455	10.937	－6.657
P值	?	0.160	0.158	<0.001	<0.001	<0.001

Please choose a citation manager

Content to export