Abstract:
Objective To investigate the risk factors of recurrent preeclampsia.
Methods Retrospective analysis was performed on 193 patients from January 2009 to December 2019 in the Third Affiliated Hospital of Guangzhou Medical University. Women with consecutive deliveries within this time frame and complicated with preeclampsia in the first delivery were included in this cohort. According to whether the second pregnancy was complicated with preeclampsia, they were divided into the recurrent preeclampsia group (56 cases) and the non-recurrent preeclampsia group (137 cases). Data was analyzed with Chi-square test and binary logistic regression.
Results (1) Compared with the non-recurrence group, the recurrence group has higher rate of more than 2 times of parities (58.93% vs 48.91%), shorter interval of pregnancy (19.65%、25.00%、16.07%、39.39% vs 3.65%、29.93%、26.28%、40.15%) and lower rate of vaginal delivery history(17.86% vs 37.23%), the difference was statistically significant (P<0.05). (2) Compared with one year interval of pregnancy, the 2 years interval of gestation (OR=0.109, 95%CI: 0.028-0.423), 3 years (OR=0.056, 95%CI: 0.013-0.246), more than 4 years (OR=0.080, 95%CI: 0.020-0.321) and a history of vaginal delivery (OR=0.199, 95%CI: 0.075-0.525) were protective factors for recurrent preeclampsia. Parties more than 2 times (OR=4.950, 95%CI: 1.848-13.262) was a risk factor for recurrent preeclampsia.
Conclusions Pregnancy interval, history of vaginal delivery and parity are the main factors affecting the recurrent preeclampsia.
Key words:
Preeclampsia,
Recurrent,
Risk factors
Wen Sun, Xiaoyi Wang, Lin Yu, Lin Lin, Yong Wang, Hao Yan, Yunzhe Xu, Shifeng Gu, Chunhong Su, Dunjin Chen. The risk factors of recurrent preeclampsia[J]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2021, 10(02): 101-104.