The risk factors of recurrent preeclampsia

doi:10.3877/cma.j.issn.2095-3259.2021.02.008

Abstract

Abstract:

Objective

To investigate the risk factors of recurrent preeclampsia.

Methods

Retrospective analysis was performed on 193 patients from January 2009 to December 2019 in the Third Affiliated Hospital of Guangzhou Medical University. Women with consecutive deliveries within this time frame and complicated with preeclampsia in the first delivery were included in this cohort. According to whether the second pregnancy was complicated with preeclampsia, they were divided into the recurrent preeclampsia group (56 cases) and the non-recurrent preeclampsia group (137 cases). Data was analyzed with Chi-square test and binary logistic regression.

Results

(1) Compared with the non-recurrence group, the recurrence group has higher rate of more than 2 times of parities (58.93% vs 48.91%), shorter interval of pregnancy (19.65%、25.00%、16.07%、39.39% vs 3.65%、29.93%、26.28%、40.15%) and lower rate of vaginal delivery history(17.86% vs 37.23%), the difference was statistically significant (P<0.05). (2) Compared with one year interval of pregnancy, the 2 years interval of gestation (OR=0.109, 95%CI: 0.028-0.423), 3 years (OR=0.056, 95%CI: 0.013-0.246), more than 4 years (OR=0.080, 95%CI: 0.020-0.321) and a history of vaginal delivery (OR=0.199, 95%CI: 0.075-0.525) were protective factors for recurrent preeclampsia. Parties more than 2 times (OR=4.950, 95%CI: 1.848-13.262) was a risk factor for recurrent preeclampsia.

Conclusions

Pregnancy interval, history of vaginal delivery and parity are the main factors affecting the recurrent preeclampsia.

Key words: Preeclampsia, Recurrent, Risk factors

Wen Sun, Xiaoyi Wang, Lin Yu, Lin Lin, Yong Wang, Hao Yan, Yunzhe Xu, Shifeng Gu, Chunhong Su, Dunjin Chen. The risk factors of recurrent preeclampsia[J]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2021, 10(02): 101-104.

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Figures/Tables 2

References 12

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分组	例数(例)	年龄		孕次		产次
分组	例数(例)	20～35岁	≥35岁	≤2次	>2次	≤1次	>1次
复发组	56	40(71.43)	16(28.57)	23(41.07)	33(58.93)	43(76.79)	13(23.21)
对照组	137	94(68.61)	43(31.39)	70(51.09)	67(48.91)	127(92.70)	10(7.30)
χ²值		0.149		1.600		9.592
P值		0.700		0.206		0.002
分组	例数(例)	阴道分娩史	孕前体重指数(kg/m²)				孕期规律产检
分组	例数(例)	阴道分娩史	<18.5	18.5～24.99	25～29.99	≥30	孕期规律产检
复发组	56	10(17.86)	5(8.93)	36(64.29)	11(19.64)	4(7.14)	19(33.93)
对照组	137	51(37.23)	14(10.22)	79(57.66)	32(23.36)	12(8.76)	61(44.53)
χ²值		6.899	0.738				1.839
P值		0.009	0.864				0.175
分组	例数(例)	妊娠合并内科疾病	妊娠间隔
分组	例数(例)	妊娠合并内科疾病	1年	2年	3年	≥4年
复发组	56	18(32.14)	11(19.64)	14(25.00)	9(16.07)	22(39.29)
对照组	137	36(26.28)	5(3.65)	41(29.93)	36(26.28)	55(40.15)
χ²值		0.679	13.040
P值		0.410	0.005

分组	例数(例)	年龄		孕次		产次
分组	例数(例)	20～35岁	≥35岁	≤2次	>2次	≤1次	>1次
复发组	56	40(71.43)	16(28.57)	23(41.07)	33(58.93)	43(76.79)	13(23.21)
对照组	137	94(68.61)	43(31.39)	70(51.09)	67(48.91)	127(92.70)	10(7.30)
χ²值		0.149		1.600		9.592
P值		0.700		0.206		0.002
分组	例数(例)	阴道分娩史	孕前体重指数(kg/m²)				孕期规律产检
分组	例数(例)	阴道分娩史	<18.5	18.5～24.99	25～29.99	≥30	孕期规律产检
复发组	56	10(17.86)	5(8.93)	36(64.29)	11(19.64)	4(7.14)	19(33.93)
对照组	137	51(37.23)	14(10.22)	79(57.66)	32(23.36)	12(8.76)	61(44.53)
χ²值		6.899	0.738				1.839
P值		0.009	0.864				0.175
分组	例数(例)	妊娠合并内科疾病	妊娠间隔
分组	例数(例)	妊娠合并内科疾病	1年	2年	3年	≥4年
复发组	56	18(32.14)	11(19.64)	14(25.00)	9(16.07)	22(39.29)
对照组	137	36(26.28)	5(3.65)	41(29.93)	36(26.28)	55(40.15)
χ²值		0.679	13.040
P值		0.410	0.005

项目		β值	Wald值	P值	OR值	95%CI值
妊娠间隔
	2年^a	-2.220	10.242	0.001	0.109	0.028～0.423
	3年^a	-2.889	14.502	0.000	0.056	0.013～0.246
	≥4年^a	-2.523	12.741	0.000	0.080	0.020～0.321
阴道分娩史		-1.615	10.621	0.001	0.199	0.075～0.525
产次		1.599	10.621	0.001	4.950	1.848～13.262

项目		β值	Wald值	P值	OR值	95%CI值
妊娠间隔
	2年^a	-2.220	10.242	0.001	0.109	0.028～0.423
	3年^a	-2.889	14.502	0.000	0.056	0.013～0.246
	≥4年^a	-2.523	12.741	0.000	0.080	0.020～0.321
阴道分娩史		-1.615	10.621	0.001	0.199	0.075～0.525
产次		1.599	10.621	0.001	4.950	1.848～13.262

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