Pathogenesis of thrombophilia in pregnancy

doi:10.3877/cma.j.issn.2095-3259.2023.02.001

Abstract

Abstract:

Thrombophilia in pregnancy includes both inherited and acquired. Hereditary thrombophilia involves changes in the factors involved in coagulation and fibrinolysis due to genetic alterations, and their relationship with adverse pregnancy outcomes is still unclear. The acquired thrombophilias are mainly associated with antiphospholipid syndrome, in which the spectrum of antiphospholipid antibodies play a key role in the pathogenesis of the disease, inducing activation of various cells, inflammation and the complement system, leading to the occurrence of thrombosis and adverse pregnancy outcomes. This article reviews the pathogenesis of thrombophilia in pregnancy.

Key words: Thrombosis, Pregnancy

Lele Wang, Huishu Liu. Pathogenesis of thrombophilia in pregnancy[J]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2023, 12(02): 65-70.

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