Assisted reproductive technology and fetal growth disorders

doi:10.3877/cma.j.issn.2095-3259.2024.02.006

Abstract

Abstract:

The impact of assisted reproductive technology on fetal growth can be manifested as fetal growth restriction or fetal overgrowth, and the risk is related to the type of embryo transferred. The specific mechanisms by which assisted reproductive technology affects fetal growth have not been fully defined, and different mechanisms are thought to play a key role in early placentation defects.

Key words: Reproductive techniques, assisted, Fertilization in vitro, Embryo transfer, Fetal development, Placentation

Xing Wei, Luming Sun. Assisted reproductive technology and fetal growth disorders[J]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2024, 13(02): 88-92.

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References 42

[1]	Chambers GM, Dyer S, Zegers-Hochschild F, et al. International Committee for Monitoring Assisted Reproductive Technologies world report: assisted reproductive technology, 2014[J]. Hum Reprod，2021，36(11)：2921-2934.
[2]	Fauser BC. Towards the global coverage of a unified registry of IVF outcomes[J]. Reprod Biomed Online，2019，38(2)：133-137.
[3]	王春燕，王婕妤，程静娴，等．辅助生殖技术与子代安全[J]. 国际生殖健康/计划生育杂志，2023，42(3)：226-230.
[4]	Jackson RA, Gibson KA, Wu YW, et al. Perinatal outcomes in singletons following in vitro fertilization: a meta-analysis[J]. Obstet Gynecol，2004，103(3)：551-563.
[5]	McDonald SD, Han Z, Mulla S, et al. Preterm birth and low birth weight among in vitro fertilization singletons: a systematic review and meta-analyses[J]. Eur J Obstet Gynecol Reprod Biol，2009，146(2)：138-148.
[6]	Choux C, Ginod P, Barberet J, et al. Placental volume and other first-trimester outcomes: are there differences between fresh embryo transfer, frozen-thawed embryo transfer and natural conception？[J]. Reprod Biomed Online，2019，38(4)：538-548.
[7]	Thomopoulos C, Tsioufis C, Michalopoulou H, et al. Assisted reproductive technology and pregnancy-related hypertensive complications: a systematic review[J]. J Hum Hypertens，2013，27(3)：148-157.
[8]	Saito K, Kuwahara A, Ishikawa T, et al. Endometrial preparation methods for frozen-thawed embryo transfer are associated with altered risks of hypertensive disorders of pregnancy, placenta accreta, and gestational diabetes mellitus[J]. Hum Reprod，2019，34(8)：1567-1575.
[9]	Bloise E, Lin W, Liu X, et al. Impaired placental nutrient transport in mice generated by in vitro fertilization[J]. Endocrinology，2012，153(7)：3457-3467.
[10]	Lalosević D, Tabs D, Krnojelac D, et al. Histological characteristics of placentas from assisted reproduction programs[J]. Med Pregl，2003，56(11-12)：521-527.
[11]	Joy J, Gannon C, McClure N, et al. Is assisted reproduction associated with abnormal placentation？[J]. Pediatr Dev Pathol，2012，15(4)：306-314.
[12]	Pereira N, Reichman DE, Goldschlag DE, et al. Impact of elevated peak serum estradiol levels during controlled ovarian hyperstimulation on the birth weight of term singletons from fresh IVF-ET cycles[J]. J Assist Reprod Genet，2015，32(4)：527-532.
[13]	Weinerman R, Ord T, Bartolomei MS, et al. The superovulated environment, independent of embryo vitrification, results in low birthweight in a mouse model[J]. Biol Reprod，2017，97(1)：133-142.
[14]	Rosario FJ, Jansson N, Kanai Y, et al. Maternal protein restriction in the rat inhibits placental insulin, mTOR, and STAT3 signaling and down-regulates placental amino acid transporters[J]. Endocrinology，2011，152(3)：1119-1129.
[15]	Rosario FJ, Schumacher MA, Jiang J, et al. Chronic maternal infusion of full-length adiponectin in pregnant mice down-regulates placental amino acid transporter activity and expression and decreases fetal growth[J]. J Physiol，2012，590(6)：1495-1509.
[16]	Kavitha JV, Rosario FJ, Nijland MJ, et al. Down-regulation of placental mTOR, insulin/IGF-I signaling, and nutrient transporters in response to maternal nutrient restriction in the baboon[J]. FASEB J，2014，28(3)：1294-1305.
[17]	Rosario FJ, Gupta MB, Myatt L, et al. Mechanistic Target of Rapamycin Complex 1 Promotes the Expression of Genes Encoding Electron Transport Chain Proteins and Stimulates Oxidative Phosphorylation in Primary Human Trophoblast Cells by Regulating Mitochondrial Biogenesis[J]. Sci Rep，2019，9(1)：1-14.
[18]	Kalra SK, Ratcliffe SJ, Coutifaris C, et al. Ovarian stimulation and low birth weight in newborns conceived through in vitro fertilization[J]. Obstet Gynecol，2011，118(4)：863-871.
[19]	Moshkdanian G, Moghani-Ghoroghi F, Pasbakhsh P, et al. Melatonin upregulates ErbB1 and ErbB4, two primary implantation receptors, in pre-implantation mouse embryos[J]. Iran J Basic Med Sci，2017，20(6)：655-661.
[20]	Pinborg A, Wennerholm UB, Romundstad LB, et al. Why do singletons conceived after assisted reproduction technology have adverse perinatal outcome? Systematic review and meta-analysis[J]. Hum Reprod Update，2013，19(2)：87-104.
[21]	Raatikainen K, Kuivasaari-Pirinen P, Hippeläinen M, et al. Comparison of the pregnancy outcomes of subfertile women after infertility treatment and in naturally conceived pregnancies[J]. Hum Reprod，2012，27(4)：1162-1169.
[22]	Draper ES, Kurinczuk JJ, Abrams KR, et al. Assessment of separate contributions to perinatal mortality of infertility history and treatment: a case-control analysis[J]. Lancet，1999，353(9166)：1746-1749.
[23]	Cooper AR, O'Neill KE, Allsworth JE, et al. Smaller fetal size in singletons after infertility therapies: the influence of technology and the underlying infertility[J]. Fertil Steril，2011，96(5)：1100-1106.
[24]	Libby V, DeVilbiss E, Chung M, et al. Obstetric outcomes in pregnancies resulting from in vitro fertilization are not different in fertile, sterilized women compared to infertile women: a Society for Assisted Reproductive Technology database analysis[J]. Fertil Steril，2021，115(3)：617-626.
[25]	黄雨瞳，盛建中，黄荷凤. 卵子玻璃化冷冻对表观遗传及基因表达的影响[J]. 中国计划生育和妇产科，2023，15(3)：19-24.
[26]	DeBaun MR, Niemitz EL, Feinberg AP. Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and H19[J]. Am J Hum Genet，2003，72(1)：156-160.
[27]	Gicquel C, Gaston V, Mandelbaum J, et al. In vitro fertilization may increase the risk of Beckwith-Wiedemann syndrome related to the abnormal imprinting of the KCN1OT gene[J]. Am J Hum Genet，2003，72(5)：1338-1341.
[28]	Halliday J, Oke K, Breheny S, et al. Beckwith-Wiedemann syndrome and IVF: a case-control study[J]. Am J Hum Genet，2004，75(3)：526-528.
[29]	Constancia M, Hemberger M, Hughes J, et al. Placental-specific IGF-II is a major modulator of placental and fetal growth[J]. Nature，2002，417(6892)：945-948.
[30]	Håberg SE, Page CM, Lee Y, et al. DNA methylation in newborns conceived by assisted reproductive technology[J]. Nat Commun，2022，13(1)：1-12.
[31]	Besharati M, von Versen-Höynck F, Kapphahn K, et al. Examination of fetal growth trajectories following infertility treatment[J]. J Assist Reprod Genet，2020，37(6)：1399-1407.
[32]	周晶，陈书强，黄剑磊，等. 新鲜周期与冻融周期胚胎移植助孕后胎儿宫内生长轨迹的比较分析[J]. 中国计划生育和妇产科，2022，14(11)：65-68.
[33]	Di Tommaso M, Sisti G, Colombi I, et al. Influence of assisted reproductive technologies on maternal and neonatal outcomes in early preterm deliveries[J]. J Gynecol Obstet Hum Reprod，2019，48(10)：845-848.
[34]	Lei LL, Lan YL, Wang SY, et al. Perinatal complications and live-birth outcomes following assisted reproductive technology: a retrospective cohort study[J]. Chin Med J (Engl)，2019，132(20)：2408-2416.
[35]	Sermondade N, Hesters L, De Mouzon J, et al. Fetal growth disorders following medically assisted reproduction: due to maternal context or techniques? A national French cohort study[J]. Reprod Biomed Online，2023，46(4)：739-749.
[36]	Berntsen S, Pinborg A. Large for gestational age and macrosomia in singletons born after frozen/thawed embryo transfer (FET) in assisted reproductive technology (ART)[J]. Birth Defects Res，2018，110(8)：630-643.
[37]	Westvik-Johari K, Romundstad LB, Lawlor DA, et al. Separating parental and treatment contributions to perinatal health after fresh and frozen embryo transfer in assisted reproduction: A cohort study with within-sibship analysis[J]. PLoS Med，2021，18(6)：1-20.
[38]	Vidal M, Vellvé K, González-Comadran M, et al. Perinatal outcomes in children born after fresh or frozen embryo transfer: a Catalan cohort study based on 14，262 newborns[J]. Fertil Steril，2017，107(4)：940-947.
[39]	Pinborg A, Henningsen AA, Loft A, et al. Large baby syndrome in singletons born after frozen embryo transfer (FET): is it due to maternal factors or the cryotechnique？[J]. Hum Reprod，2014，29(3)：618-627.
[40]	Sun L, Zou G, Wei X, et al. Clinical outcomes after assisted reproductive technology in twin pregnancies: chorionicity-based comparison[J]. Sci Rep，2016，6：1-7.
[41]	Seravalli V, Maoloni L, Pasquini L, et al. The impact of assisted reproductive technology on prenatally diagnosed fetal growth restriction in dichorionic twin pregnancies[J]. PLoS One，2020，15(4)：1-10.
[42]	Kondowe FJM, Clayton P, Gittins M, et al. Growth of twins conceived using assisted reproductive treatments up to 5 years old: a national growth cohort[J]. Hum Reprod，2023，38(4)：751-761.

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