To explore the risk factors and delivery outcomes of placenta previa during in vitro fertilization-embryo transfer.

Collect the clinical data of 5401 women who had assisted reproductive technology pregnancy in our hospital from January 2018 to December 2023 and delivered in hospital. Among them, 192 patients with placenta previa were the study group and 5209 patients with non-placenta previa were the control group. Compare the general clinical data and maternal and infant outcomes between two groups of patients.

Compared with the control group, the age≥35(47.40% vs 37.82%, χ²=7.20), cesarean section history (19.79% vs 9.50%, χ²=22.04), parity≥1 (38.54% vs 24.75%, χ²=18.68), polycystic ovary syndrome (8.33% vs 16.74%, χ²=9.53), reduced ovarian reserve (8.85% vs 5.39% χ²=4.25), male factor infertility (22.40% vs 29.33%, χ²=4.32), and the incidence of endometriosis (21.88% vs 8.49%, χ²=40.69) were significantly different (P<0.05). Further multivariate logistic regression analysis showed that excessive labor (OR=1.54, 95%CI: 1.05~2.27, P<0.05) and endometriosis (OR=2.88, 95%CI: 1.99~4.16, P<0.05) were independent risk factors for placenta previa in pregnant women undergoing IVF embryo transfer pregnancy, while polycystic ovary syndrome (OR=0.55, 95%CI: 0.33~0.94, P<0.05) was the protective factor. The hospital days [(9.19±6.60)d vs (6.10±4.62)d, t=25.51], intraoperative blood loss [(727.85±507.12)ml vs (498.34±250.54)ml, t=96.38], postpartum bleeding rate (18.23% vs 11.19%, χ²=9.05), and birth weight [(2668.35±641.00)g vs (2801.91±697.68)g, t=5.44] showed significant differents between the study group and the control group (P<0.05).

Multiparity and endometriosis are independent risk factors for placenta previa in pregnancy patients with in vitro fertilization-embryo transfer, and polycystic ovary syndrome is a protective factor. Plenta previa patients have more adverse pregnancy outcomes, longer hospitalization, the postpartum bleeding larger, postpartum bleeding rate is higher, and newborn body quality is lower, the occurrence of placenta previa can increase the hospital stay, postpartum bleeding rate and low birth quality, should strictly grasp the in vitro fertilization-embryo transfer indications, strengthen the management of patients with placenta previa.