Detection research in noninvasive prenatal diagnosis of cell-free fetal DNA in maternal plasma

doi:10.3877/cma.j.issn.2095-3259.2017.04.008

Abstract

Abstract:

The discovery and research of cell-free fetal DNA (cffDNA) greatly promoted the development of noninvasive prenatal testing (NIPT). With the continuous optimization of high-throughput sequencing technology and the development of bioinformatics, NIPT showed its wide application prospects and clinical value from 21-trisomy syndrome, 18-trisomy syndrome and 13-trisomy syndrome chromosomal aneuploidy to copy number variation and single gene disease research. This article focuses on the detection research progress of cffDNA by NIPT.

Key words: Base Sequence, Prenatal diagnosis, Sequence analysis, Fetal diseases

Yanchou Ye, Jun Zhang. Detection research in noninvasive prenatal diagnosis of cell-free fetal DNA in maternal plasma[J]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2017, 06(04): 223-227.

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