To investigate the clinical characteristics, diagnosis, treatment, and causes of death in patients with pregnancy complicated by tumors.

A retrospective analysis was conducted on the clinical data of 6 maternal death cases involving pregnancy complicated by tumors in Fujian Province from January to December 2021.

Among the 6 cases, three were gastric cancer, one was pulmonary adenocarcinoma, one was pulmonary lymphangioleiomyomatosis, and one was rhabdomyosarcoma. 4 cases were misdiagnosed or missed (including 1 case where the patient concealed her medical history and refused specialized examinations). Distant or systemic metastasis occurred in 3 cases. Only one patient was eligible to receive tumor-specific treatment, while the others received only symptomatic and supportive care. Two maternal deaths occurred after termination of pregnancy by cesarean section, two occurred following intrauterine fetal death, and the remaining two occurred during pregnancy. All six patients died due to tumor progression.

Tumors complicating pregnancy are characterized by insidious symptoms, high rates of misdiagnosis and missed diagnosis, advanced tumor stages at diagnosis, rapid progression, and poor prognosis. In clinical practice, multidisciplinary collaboration should be strengthened to improve outcomes through early diagnosis, timely treatment, and individualized decision-making.