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中华产科急救电子杂志 ›› 2023, Vol. 12 ›› Issue (02) : 76 -80. doi: 10.3877/cma.j.issn.2095-3259.2023.02.003

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妊娠期易栓症的自身抗体检测
杨泽俊, 赵茵()   
  1. 华中科技大学同济医学院附属协和医院妇产科,武汉 430030
    华中科技大学同济医学院附属协和医院妇产科,武汉 430030;华中科技大学深圳研究院,深圳 518000
  • 收稿日期:2022-10-08 出版日期:2023-05-18
  • 通信作者: 赵茵
  • 基金资助:
    国家自然科学基金(82171678); 深圳市自然科学基金(JCY20200109140614667)

Detection of autoantibodies in thrombophilia of pregnancy

Zejun Yang, Yin Zhao()   

  • Received:2022-10-08 Published:2023-05-18
  • Corresponding author: Yin Zhao
引用本文:

杨泽俊, 赵茵. 妊娠期易栓症的自身抗体检测[J]. 中华产科急救电子杂志, 2023, 12(02): 76-80.

Zejun Yang, Yin Zhao. Detection of autoantibodies in thrombophilia of pregnancy[J]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2023, 12(02): 76-80.

妊娠期孕妇血液呈高凝状态,在遗传性因素或获得性因素的影响下,孕妇血液的高凝状态更严重。妊娠期易栓症不仅增加静脉血栓栓塞的风险,还可导致不良围产结局,严重危害母婴健康。获得性易栓症的诊断主要依赖临床症状和实验室检查,其中自身抗体是主要的实验室指标。本文主要对妊娠期易栓症自身抗体的种类、在发病机制中的作用、实验室检测方法和诊断价值的研究进展进行论述。

The blood of pregnant women during pregnancy is hypercoagulable. Under the influence of hereditary or acquired factors, the hypercoagulable state of pregnant women′s blood is more serious. Thrombophilia during pregnancy not only increases the risk of venous thromboembolism but also leads to adverse perinatal outcomes, which seriously endangers the health of mothers and infants. The diagnosis of acquired thrombophilia mainly depends on clinical symptoms and laboratory tests, in which autoantibodies are the main laboratory indicators. This review focuses on the research progress of the types of autoantibodies, their role in pathogenesis, laboratory testing methods and diagnostic value in thrombophilia in pregnancy.

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