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中华产科急救电子杂志 ›› 2025, Vol. 14 ›› Issue (02) : 86 -94. doi: 10.3877/cma.j.issn.2095-3259.2025.02.005

论著

妊娠合并高甘油三酯血症性急性胰腺炎的临床研究
李兆蕾1, 詹敏金2, 陈海天1,()   
  1. 1. 中山大学附属第一医院妇产科,广州 510080
    2. 中山大学附属第一医院惠亚医院妇产科,广东 惠州 516081
  • 收稿日期:2024-09-12 出版日期:2025-05-18
  • 通信作者: 陈海天
  • 基金资助:
    国家重点研发计划(2021YFC2700703)

Clinical research on hyper-triglyceridemic acute pancreatitis in pregnancy

Zhaolei Li1, Minjin Zhan2, Haitian Chen1,()   

  1. 1. Department of Obstetrics and Gynecology,The First Affiliated Hospital of Sun Yatsen University,Guangzhou,China 510080
    2. Department of Obstetrics and Gynecology,Hui Ya Hospital of The First Affiliated Hospital of Sun Yat-sen University,Huizhou,China 516081
  • Received:2024-09-12 Published:2025-05-18
  • Corresponding author: Haitian Chen
引用本文:

李兆蕾, 詹敏金, 陈海天. 妊娠合并高甘油三酯血症性急性胰腺炎的临床研究[J/OL]. 中华产科急救电子杂志, 2025, 14(02): 86-94.

Zhaolei Li, Minjin Zhan, Haitian Chen. Clinical research on hyper-triglyceridemic acute pancreatitis in pregnancy[J/OL]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2025, 14(02): 86-94.

目的

总结分析妊娠合并高甘油三酯血症性急性胰腺炎患者的临床特点、诊治过程和母儿结局,优化该疾病的妊娠期及围产期管理。

方法

回顾性分析2014年1月1日至2023年12月31日在中山大学附属第一医院住院治疗并分娩的8例妊娠合并高甘油三酯血症性急性胰腺炎患者的临床资料,总结其临床特点、治疗方法、妊娠结局和新生儿预后。

结果

8例患者中1例为双胎妊娠。8例均于妊娠中晚期起病,2例合并子痫前期,3例孕期发现血糖异常,2例合并凝血功能障碍,5例合并低钾血症;8例患者均剖宫产终止妊娠,其中6例转ICU治疗。9例新生儿中活产8例,死亡1例。

结论

妊娠合并高甘油三酯血症性急性胰腺炎罕见但危重,病情进展快,严重可致母儿死亡,需要多学科团队进行确诊和管理。

Objective

To analyze the clinical characteristics,diagnosis and treatment methods,maternal-fetal outcomes in patients with hyper-triglyceridemic acute pancreatitis in pregnancy,and optimize the management of this disease during pregnancy and perinatal period.

Methods

The clinical data of 8 patients with hyper-triglyceridemic acute pancreatitis in pregnancy who were hospitalized and delivered in the First Affiliated Hospital of Sun Yat-sen University from January 1,2014 to December 31,2023 were retrospectively collected.The clinical characteristics,treatment methods,pregnancy outcomes and neonatal prognosis were summarized.

Results

1 in 8 patients had a twin pregnancy.All 8 patients had onset during the second and third trimesters of pregnancy.2 cases were complicated with pre-eclampsia,3 cases had abnormal blood glucose,2 cases were complicated with abnormal coagulation function,and 5 cases were complicated with hypokalemia.All underwent cesarean delivery,with 6 cases requiring ICU admission.Among 9 neonatal,8 survived and 1 died.

Conclusions

Hyper-triglyceridemic acute pancreatitis in pregnancy is a rare but life-threatening obstetric emergency characterized by rapid progression and high maternal-fetal mortality,necessitating multidisciplinary team management.

表1 8例妊娠合并高甘油三酯血症性急性胰腺炎患者的一般情况
表2 8例妊娠合并高甘油三酯血症性急性胰腺炎患者的临床表现与辅助检查
表3 8例妊娠合并高甘油三酯血症性急性胰腺炎患者实验室指标的围产期变化
表4 8例妊娠合并高甘油三酯血症性急性胰腺炎患者的治疗措施
表5 8例妊娠合并高甘油三酯血症性急性胰腺炎患者的临床结局
表6 8例妊娠合并高甘油三酯血症性急性胰腺炎患者的胎儿及新生儿结局
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