To review and summarize the clinical features and treatment of amyotrophic lateral sclerosis in the pregnant women.

To studies the clinical manifestation, treatment and the outcome of 1 pregnancy woman with amyotrophic lateral sclerosis in the First Affiliated Hospital of Sun Yat-sen University and previous 13 literature reports.

There were 14 cases of amyotrophic lateral sclerosis during pregnancy and 16 times deliveries. For clinical manifestation, 6 cases had respiratory insufficiency, 4 cases had weakness of limbs, and 3 cases died of respiratory failure after delivery. For the outcome of delivery, 6 cases were premature deliveries, 5 cases were term deliveries, and 1 case was therapeutic abortion. No cases died of obstetric complications.

Respiratory failure is the main cause of maternal mortality in pregnant women with amyotrophic lateral sclerosis. Multidisciplinary cooperation closed monitoring and treatments of complications in time are necessary in perinatal period.